Product

Cefpirome sulfate

CAS No.：98753-19-6

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Cefpirome sulfate Basic information

Product Name:	Cefpirome sulfate
Synonyms:	1-[[(6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-6,7-dihydro-5h-cyclopenta[b]pyridinium sulfate;CEFPIROME SULFATE;Keitin);Cefquinome base;CefpiromeSulfate3%;1-(((6R,7R)-7-((Z)-2-(2-AMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)Methyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-1-iuM hydrogensulfate;CEFPIROME SULFATE USP 27;(6r-rboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-
CAS:	98753-19-6
MF:	C22H24N6O9S3
MW:	612.66
EINECS:	685-392-7
Product Categories:	api;Pharmaceutical intermediate;cephalosporins antibiotics;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;Antibacterial;Miscellaneous
Mol File:	98753-19-6.mol

Cefpirome sulfate Chemical Properties

Melting point	198-2020C (dec)
alpha	25D -4.7° (c = 5 in H2O)
RTECS	UW8970000
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO
form	Solid
color	White to Off-White
λmax	265nm(Buffer)(lit.)
Merck	14,1940
CAS DataBase Reference	98753-19-6(CAS DataBase Reference)

Safety Information

MSDS Information

Cefpirome sulfate Usage And Synthesis

Description	Cefpirome sulfate is a new injectable cephalosporin indicated for the treatment of severe urinary and respiratory tract infections, including septicemia and nosocomial infections. Cefpirome sulfate is reported to be the first true fourth-generation cephalosporin due to its similar activities to third-generation antibiotics against Gram-positive bacteria and to first-generation antibiotics against Gram-negative bacteria. Its efficacy against P.aeruginosa is comparable to ceftazidime. The broad spectrum of activity includes Klebsiella, methicillin-sensitive staphylococci, penicillin-resistant pneumococci, E.coli which generates extended-spectrum beta-lactamases and multi-resistant organisms such as Citrobacter, Enterobacter and Serratia.
Chemical Properties	White Crystalline Powder
Originator	Hoechst AG (Germany)
Uses	A fourth generation cephalosporin antibiotic
Uses	Fourth generation cephalosporin antibiotic
Brand name	Cefrom (Hoechst-Roussel).

Cefpirome sulfate Preparation Products And Raw materials

Raw materials

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-(iodomethyl)-8-oxo-7-[(2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)--->GCLE-->S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate-->Cyclopenta[b]pyridine-->S-benzothiazol-2-yl 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)thioacetate

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