5-Chloro-2-methoxybenzoic acid

CAS No.：3438-16-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-Chloro-2-methoxybenzoic acid Basic information

Product Name:	5-Chloro-2-methoxybenzoic acid
Synonyms:	2-Carboxy-4-chloroanisole;5-Chloro-N-(2-phenylethyl)-2-MethoxybenzaMide;Glyburide IMP;RARECHEM AL BO 0576;5-Chloro-o-anisic acid,99%;2-METHOXY-5-CHLOROBENZOIC ACID;5-CHLORO-2-METHOXYBENZOIC ACID;5-CHLORO-2-ANISIC ACID
CAS:	3438-16-2
MF:	C8H7ClO3
MW:	186.59
EINECS:	222-343-7
Product Categories:	API Intermediate;FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;(intermediate of glibenclamide);Miscellaneous;Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds
Mol File:	3438-16-2.mol

5-Chloro-2-methoxybenzoic acid Chemical Properties

Melting point	98-100 °C (lit.)
Boiling point	150-152C
density	1,259g/cm
refractive index	1,544-1546
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Crystalline Powder
pka	3.72±0.10(Predicted)
color	White to off-white
CAS DataBase Reference	3438-16-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29189900

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

5-Chloro-2-methoxybenzoic acid Usage And Synthesis

Chemical Properties	White to off-white crystalline powder
Uses	5-Chloro-2-methoxybenzoic acid has been used in the synthesis of 5-chloro-2-methoxybenzoates of La(III), Ga(III) and Lu(III).
General Description	Complexes of 4-chloro-2-methoxybenzoic acid anion with Mn²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺have been investigated.

5-Chloro-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials	Dimethyl sulfate-->5-Chloro-2-hydroxybenzoic acid
Preparation Products	4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE-->5-CHLORO-2-METHOXYBENZOYL CHLORIDE-->4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide-->PF-06282999-->IMD-0354

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