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| Glyoxylic acid Basic information |
| Glyoxylic acid Chemical Properties |
| Melting point | -93°C | | Boiling point | 111°C | | density | 1.33 g/mL at 20 °C | | vapor pressure | 14hPa at 19.85℃ | | refractive index | n20/D 1.414 | | Fp | 111°C | | storage temp. | Store below +30°C. | | solubility | Miscible with ethanol. Slightly miscible with ether and benzene. Immiscible with esters. | | pka | 3.18(at 25℃) | | form | clear liquid | | color | Colorless to Light orange to Yellow | | Water Solubility | miscible | | Merck | 14,4511 | | BRN | 741891 | | InChIKey | HHLFWLYXYJOTON-UHFFFAOYSA-N | | CAS DataBase Reference | 298-12-4(CAS DataBase Reference) | | NIST Chemistry Reference | Acetic acid, oxo-(298-12-4) | | EPA Substance Registry System | Acetic acid, 2-oxo- (298-12-4) |
| Glyoxylic acid Usage And Synthesis |
| Chemical Properties | Colorless clear liquid. | | Uses | Glyoxalic acid can be used in the synthesis of a variety of reactions.Glyoxylic acid is used in Hopkins Cole reaction, which is used in the detection of tryptophan in proteins. It reacts with phenol to get 4-hydroxymandelic acid, which on further reaction with ammonia gives hydroxyphenylglycine, as a precursor to the drug amoxicillin. It is also used as a starting material for the preparation of 4-hydroxyphenylacetic acid, which is used to get atenolol. | | Definition | ChEBI: A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom. | | General Description | Supplied as a 50% aqueous solution. | | Health Hazard | Contact will cause severe eye and skin burns. Vapor exposure may cause eye and skin irritation. | | Flammability and Explosibility | Nonflammable | | Biological Activity | nsc 27785 is an organic compound that is both an aldehyde and a carboxylic acid. | | Synthesis | Add to 3500ml reactor equipped with reflux condenser, stirrer and thermometer300ml (3.55mol) of 50% glyoxal solution, stir and cool, control the temperature to 7±2,Slowly drip 300ml (3.55mol) of 35% hydrogen peroxide solution at the same time within 3 hours,280ml (0.355mol) of 17% ferrous sulfate solution and 120ml (0.75mol) of 15% aqueous ammonia solution, keep at 8±2, react for 3 hours, and let stand overnight, The reaction liquid was filtered to remove the solid by-products, and 350ml of water-carrying toluene was added to the reaction mother liquid.Heat to reflux, remove water, and distill toluene with water-carrying agent to obtain oxidation product.Add 120ml of concentrated sulfuric acid and 700ml of absolute ethanol to the oxidation products.Esterification reaction at 140°C for 3 hours, then distillation under reduced pressure, at 0.02Mpa,The esterification product was collected at 185°C.Add 120ml of 18% sulfuric acid to the esterified product and heat under stirring.The hydrolysis reaction is carried out at 95-98 for 2 hours; the hydrolysis liquid is cooled to room temperature,The precipitated white solid product was filtered, washed 4 times with 120ml of toluene each time, and dried.Obtain 180 g of the target product glyoxylic acid with a purity of 99.5% (HPLC) and a yield of 88%.Melting point is 98.1-98.6. |
| Glyoxylic acid Preparation Products And Raw materials |
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