2,5-Dichloropyridine

2,5-Dichloropyridine
  • CAS No.:16110-09-1
Other grades of this product :
2,5-Dichloropyridine Basic information
Uses
Product Name:2,5-Dichloropyridine
Synonyms:2,5-Dichloropyridine, 98% 5GR;2,5- twochlorine pyridine;2,5-Dichiloropyridine;2,5-Chloro pyridine;2,5-dichloro-pyridin;2,5-DICHLORPYRIDINE;2,5-Dichloropyridine97%;Dichloropyridine
CAS:16110-09-1
MF:C5H3Cl2N
MW:147.99
EINECS:240-278-2
Product Categories:Chlorinated heterocyclic series;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Chloropyridines;Halopyridines;Pyridine;pyridine derivative;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;alkyl chloride;bc0001
Mol File:16110-09-1.mol
2,5-Dichloropyridine Chemical Properties
Melting point 59-62 °C (lit.)
Boiling point 190-191 °C
density 1.5159 (rough estimate)
refractive index 1.5500 (estimate)
Fp 112 °C
storage temp. Inert atmosphere,Room Temperature
pka-2.25±0.10(Predicted)
form Crystalline Solid
color White to slightly yellow
Water Solubility insoluble
BRN 108886
CAS DataBase Reference16110-09-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-37/39-36
RIDADR UN2811
WGK Germany 3
RTECS US8225000
Hazard Note Harmful
HazardClass IRRITANT
HazardClass 6.1
HS Code 29333990
MSDS Information
ProviderLanguage
2,5-Dichloropyridine English
SigmaAldrich English
ACROS English
ALFA English
2,5-Dichloropyridine Usage And Synthesis
Uses2,5-Dichloropyridine is a reagent used in chemical synthesis. It has been used to synthesize 4-benzodiazepine-2,5 diones as Hdm2 antagonists and inhibitors of ERK protein kinase.
Chemical Propertieswhite to slightly yellow crystalline solid
Uses2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.
Synthesis Reference(s)Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514
General Description2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

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