2-Bromo-5-fluoropyridine

CAS No.：41404-58-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Bromo-5-fluoropyridine Basic information

Product Name:	2-Bromo-5-fluoropyridine
Synonyms:	2-BROMO-5-FLUOROPYRIDINE;2--5- fluoropyridinebroMide;2-BroMo-5-fluoropyridine, 97+%;2 - broMine - 5 - fluoride pyridine;5-FLUOROPYRIDIN-2-YL-BORONIC ACID;5-FLUOROPYRIDINE-2-BORONIC ACID;2-bromo-5-fluoropyridin;2-Bromo-5-fluoropyridine98%
CAS:	41404-58-4
MF:	C5H3BrFN
MW:	175.99
EINECS:	629-269-8
Product Categories:	Fluorine series;Fluorinated;Organohalides;Bromopyridines;Fluoropyridines;Halopyridines;blocks;Bromides;Pyridine series;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Variety of halogenated heterocyclic series;Fluorin-contained pyridine series;FluoroCompounds;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;bc0001
Mol File:	41404-58-4.mol

2-Bromo-5-fluoropyridine Chemical Properties

Melting point	30-31 °C (lit.)
Boiling point	80-83 °C/44 mmHg (lit.)
density	1.707±0.06 g/cm3(Predicted)
refractive index	1.5396
Fp	167 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	-1.63±0.10(Predicted)
color	Colorless to slightly yellow
BRN	1561456
CAS DataBase Reference	41404-58-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn,F
Risk Statements	36/37/38-20/21/22-10
Safety Statements	26-36-16
RIDADR	2811
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

2-Bromo-5-fluoropyridine Usage And Synthesis

Chemical Properties	Light yellow Cryst
Uses	2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.
Uses	2-Bromo-5-fluoropyridine can be used in the synthesis of the following: 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

2-Bromo-5-fluoropyridine Preparation Products And Raw materials

Raw materials	2-Amino-5-fluoropyridine
Preparation Products	2-Cyano-5-fluoropyridine-->GNE-495-->5-FLUORO-2-IODOPYRIDINE-->5-FLUORO-2-HYDROXYMETHYL PYRIDINE-->ETHYL 5-FLUOROPYRIDINE-2-CARBOXYLATE

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