Product

2-Bromo-5-fluoropyridine

CAS No.：41404-58-4

Other grades of this product :

2-Bromo-5-fluoropyridine Basic information

Product Name:	2-Bromo-5-fluoropyridine
Synonyms:	2-BROMO-5-FLUOROPYRIDINE;2--5- fluoropyridinebroMide;2-BroMo-5-fluoropyridine, 97+%;2 - broMine - 5 - fluoride pyridine;5-FLUOROPYRIDIN-2-YL-BORONIC ACID;5-FLUOROPYRIDINE-2-BORONIC ACID;2-bromo-5-fluoropyridin;2-Bromo-5-fluoropyridine98%
CAS:	41404-58-4
MF:	C5H3BrFN
MW:	175.99
EINECS:	629-269-8
Product Categories:	Fluorine series;Fluorinated;Organohalides;Bromopyridines;Fluoropyridines;Halopyridines;blocks;Bromides;Pyridine series;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Variety of halogenated heterocyclic series;Fluorin-contained pyridine series;FluoroCompounds;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;bc0001
Mol File:	41404-58-4.mol

2-Bromo-5-fluoropyridine Chemical Properties

Melting point	30-31 °C (lit.)
Boiling point	80-83 °C/44 mmHg (lit.)
density	1.707±0.06 g/cm3(Predicted)
refractive index	1.5396
Fp	167 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	-1.63±0.10(Predicted)
color	Colorless to slightly yellow
BRN	1561456
CAS DataBase Reference	41404-58-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn,F
Risk Statements	36/37/38-20/21/22-10
Safety Statements	26-36-16
RIDADR	2811
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

2-Bromo-5-fluoropyridine Usage And Synthesis

Chemical Properties	Light yellow Cryst
Uses	2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.
Uses	2-Bromo-5-fluoropyridine can be used in the synthesis of the following: 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

2-Bromo-5-fluoropyridine Preparation Products And Raw materials

Raw materials	2-Amino-5-fluoropyridine
Preparation Products	2-Cyano-5-fluoropyridine-->GNE-495-->5-FLUORO-2-IODOPYRIDINE-->5-FLUORO-2-HYDROXYMETHYL PYRIDINE-->ETHYL 5-FLUOROPYRIDINE-2-CARBOXYLATE

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