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| 3,4-DIHYDROISOQUINOLINE Basic information |
| Product Name: | 3,4-DIHYDROISOQUINOLINE | | Synonyms: | 3,4-DIHYDROISOQUINOLINE;AKOS 213-252;3,4-Dihydroisoquinoline >=97.5% (GC);3,4-Dihydroisoquinoline ,97%;Isoquinoline, 3,4-dihydro-;3,4-DihydroisoquinoL;3,4-DIHYDROISOQUINOLINE ISO 9001：2015 REACH;4-DIHYDROISOQUINOLINE | | CAS: | 3230-65-7 | | MF: | C9H9N | | MW: | 131.17 | | EINECS: | 221-769-0 | | Product Categories: | | Mol File: | 3230-65-7.mol |
| 3,4-DIHYDROISOQUINOLINE Chemical Properties |
| Melting point | 251-254℃ | | Boiling point | 241.8±20.0℃ (760 Torr) | | density | 1.05±0.1 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.6041 (589.3 nm 30℃) | | Fp | 91.6±22.6℃ | | storage temp. | 2-8°C | | pka | 5.80±0.20(Predicted) |
| 3,4-DIHYDROISOQUINOLINE Usage And Synthesis |
| Uses | 3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors. | | Uses | 3,4-Dihydroisoquinoline can be used as a reactant to synthesize: - 5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI).
- 1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols.
- 3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.
| | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 6567, 1994 DOI: 10.1016/S0040-4039(00)78274-8 |
| 3,4-DIHYDROISOQUINOLINE Preparation Products And Raw materials |
| Raw materials | 1-(MORPHOLIN-4-YL-PHENYL-METHYL)-NAPHTHALEN-2-OL-->Formamide, N-(2-phenylethyl)--->Isoquinoline, 1,2,3,4-tetrahydro-2-hydroxy--->Isoquinoline,3,4-dihydro-, 2-oxide-->3-(Trifluoromethyl)benzaldehyde-->Isoquinoline-->N-Bromosuccinimide-->1,2,3,4-TETRAHYDROISOQUINOLINE |
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