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| 2-Phenylindole Basic information |
| 2-Phenylindole Chemical Properties |
| Melting point | 188-190 °C (lit.) | | Boiling point | 250 °C/10 mmHg (lit.) | | density | 1.1061 (rough estimate) | | refractive index | 1.5850 (estimate) | | Fp | 250°C/10mm | | storage temp. | Sealed in dry,Room Temperature | | solubility | almost transparency in Methanol | | form | Powder | | pka | 16.80±0.30(Predicted) | | color | Off-white to beige or slightly green | | CAS DataBase Reference | 948-65-2(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Indole, 2-phenyl-(948-65-2) | | EPA Substance Registry System | 1H-Indole, 2-phenyl- (948-65-2) |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | RTECS | NM1272500 | | TSCA | Yes | | HS Code | 29309090 |
| 2-Phenylindole Usage And Synthesis |
| Chemical Properties | off-white to beige or slightly green powder | | Uses | Reactant for preparation of: • ;Oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition1• ;Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators2• ;Organic light emitting diodes (OLEDs)3• ;Anti inflammatory agents4• ;Potential cyclooxygenase-1 (COX-1)/cyclooxygenase-2 (COX-2) inhibitors5• ;Agents for cancer and malaria therapy6• ;Antifungal and antibacterial agents7• ;Fluorescent probes8Reactant in:• ;Difluorohydroxylation reactions†• ;Mannich-type reactions† | | Uses | Phenylindole is a stabilizer in PVC-plastic products (α-phenylindole). | | Uses | Reactant for preparation of: - Oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition
- Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Organic light emitting diodes (OLEDs)
- Anti inflammatory agents
- Potential cyclooxygenase-1 (COX-1)/cyclooxygenase-2 (COX-2) inhibitors
- Agents for cancer and malaria therapy
- Antifungal and antibacterial agents
- Fluorescent probes
Reactant in:- Difluorohydroxylation reactions?
- Mannich-type reactions?
| | Preparation | 2-phenylindole is prepared by condensing phenylhydrazine and acetophenone, and then closing the ring in the presence of zinc chloride. or it can be prepared by heating bromoacetophenone with excess aniline, or heating N-(2-methylphenyl)benzamide and sodium ethoxide at 360-380℃ in isolation from air. | | Synthesis Reference(s) | Tetrahedron Letters, 33, p. 1459, 1992 DOI: 10.1016/S0040-4039(00)91646-0Journal of Heterocyclic Chemistry, 29, p. 1085, 1992 DOI: 10.1002/jhet.5570290509 |
| 2-Phenylindole Preparation Products And Raw materials |
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