Other grades of this product :
| nafcillin Basic information |
| Product Name: | nafcillin | | Synonyms: | (2S,5R,6R)-6-(2-Ethoxy-1-naphthoylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;6α-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]penicillanic acid;C07250;Nafcillin acid;6-(2-Ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;Nafcilin 1;Westwood acid, naphthalene;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- | | CAS: | 147-52-4 | | MF: | C21H22N2O5S | | MW: | 414.48 | | EINECS: | 205-690-9 | | Product Categories: | | Mol File: | 147-52-4.mol |
| nafcillin Chemical Properties |
| Boiling point | 714.1±60.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | pka | 2.44±0.50(Predicted) |
| nafcillin Usage And Synthesis |
| Originator | Unipen,Wyeth,US,1964 | | Uses | Antibacterial. | | Manufacturing Process | A stirred suspension of 12.6 grams 6-aminopenicillanic acid in 130 ml dry
alcohol-free chloroform was treated with 16 ml triethylamine and then with
13.8 grams of a solution of 2-ethoxy-1-naphthoyl chloride in 95 ml
chloroform. After being washed successively with 58 ml each of 1 N and then
0.1 N hydrochloric acid the chloroform solution was extracted with N aqueous
sodium bicarbonate (58 ml + 6 ml). The combined bicarbonate extracts were
washed with 20 ml ether and then evaporated at low temperature and
pressure to give the crude sodium salt of 2-ethoxy-1-naphthylpenicillin [also
called sodium 6-(2-ethoxy-1-naphthamido)penicillinate] as a yellow powder
(20.3 grams). This was dissolved in 20 ml water at 30°C and diluted with 180
ml n-butanol, also at 30°C, with stirring. Slow cooling to 0°C gave colorless
needles of the product. | | Brand name | Nallpen (GlaxoSmithKline). | | Therapeutic Function | Antibacterial |
| nafcillin Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye