Product

(S)-(-)-2-Azetidinecarboxylic acid

CAS No.：2133-34-8

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(S)-(-)-2-Azetidinecarboxylic acid Basic information

Product Name:	(S)-(-)-2-Azetidinecarboxylic acid
Synonyms:	(S)-(-)-2-AZETIDINECARBOXYLIC ACID;(S)-2-AZETIDINE CARBOXYLIC ACID;(S)-(-)-AZETIDINE-2-CARBOXYLIC ACID;(S)-AZETIDINE-2-CARBOXYLIC ACID;(S)-L-2-AZETIDINE CARBOXYLIC ACID;(2S)-(-)-AZETIDINE-2-CARBOXYLIC ACID;L-TRIMETHYLENEIMINE-2-CARBOXYLIC ACID;L-AZETIDINE-2-CARBOXYLIC ACID
CAS:	2133-34-8
MF:	C4H7NO2
MW:	101.1
EINECS:	218-362-5
Product Categories:	Amino Acids 13C, 2H, 15N;Carboxylic Acids (Chiral);Azetidines;Chiral Building Blocks;Simple 4-Membered Ring Compounds;Synthetic Organic Chemistry;Pharmaceutical Raw Materials;Nitrogen cyclic compounds;Miscellaneous;pharmacetical;chiral;API;Amino Acids & Derivatives
Mol File:	2133-34-8.mol

(S)-(-)-2-Azetidinecarboxylic acid Chemical Properties

Melting point	~215 °C (dec.)
alpha	-125 º (c=1, water 25 ºC)
Boiling point	189.47°C (rough estimate)
density	1.2245 (rough estimate)
refractive index	-122 ° (C=4, H2O)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly)
pka	2.35±0.20(Predicted)
form	Crystalline Powder or Crystals
color	White to light beige
Water Solubility	5 g/100 mL
Merck	14,908
BRN	80678
InChIKey	IADUEWIQBXOCDZ-VKHMYHEASA-N
CAS DataBase Reference	2133-34-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	3
RTECS	CM4310500
Hazard Note	Irritant
HS Code	29339900
Hazardous Substances Data	2133-34-8(Hazardous Substances Data)
Toxicity	LD50 scu-mus: 1000 mg/kg 85GDA2 8(1),101,82

MSDS Information

Provider	Language
L-2-Azetidinecarboxylic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

(S)-(-)-2-Azetidinecarboxylic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	Specific proline antagonist. Used in synthesis of abnormally high molecular weight polypeptides.
Uses	(S)-(-)-2-Azetidinecarboxylic acid is a four-membered ring analog of L-Proline, It is a useful intermediate in the synthesis of polypeptides,Used in synthesis of abnormally high molecular weight polypeptides.
Uses	L-Azetidine-2-carboxylic acid has been used as a: collagen synthesis inhibitor protein folding antagonist as a standard in liquid chromatography-mass spectrometry
Definition	ChEBI: The (S)-enantiomer of azetidine-2-carboxylic acid.
General Description	L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.
Biochem/physiol Actions	Azetidine-2-carboxylic acid (AZC) triggers protein aggregation or upregulates the expression of an aggregation-prone mutant protein, upon interference with nascent protein folding.
Safety Profile	Moderately toxic by subcutaneousroute. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.

(S)-(-)-2-Azetidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Hydrochloric acid-->Ethyl acetate-->Methanol-->Diethyl ether-->Tetrahydrofuran-->Dichloromethane-->Thionyl chloride-->PETROLEUM ETHER-->Potassium carbonate-->Sodium bicarbonate-->Palladium-->Ammonium chloride-->Acetonitrile-->Dimethyl sulfoxide-->Potassium tert-butoxide-->L-1-Phenylethylamine-->2-Bromoethanol-->Bromoacetonitrile

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