Other grades of this product :
| Product Name: | rhapontigenin | | Synonyms: | 3-benzenediol;5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1;5-[(1E)-2-(3-HYDROXY-4-METHOXYPHENYL)ETHENYL]-1;3-BENZENEDIOL;5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol;rhapontigenin;(E)-5-[2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol;3,3',5-Trihydroxy-4'-methoxy-trans-stilbene
trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene;(E)-4'-Methoxy-3,3',5-stilbenetriol | | CAS: | 500-65-2 | | MF: | C15H14O4 | | MW: | 258.27 | | EINECS: | 1312995-182-4 | | Product Categories: | | Mol File: | 500-65-2.mol |
| rhapontigenin Chemical Properties |
| Melting point | 189.0 to 193.0 °C | | Boiling point | 503.6±38.0 °C(Predicted) | | density | 1.345±0.06 g/cm3(Predicted) | | solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | powder to crystal | | pka | 9.17±0.10(Predicted) | | color | White to Light yellow | | CAS DataBase Reference | 500-65-2 |
| rhapontigenin Usage And Synthesis |
| Description | Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1. | | Description | Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM). | | Uses | Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical] | | Uses | Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1. | | references | [1]. chun yj, ryu sy, jeong tc, et al. mechanism-based inhibition of human cytochrome p450 1a1 by rhapontigenin. drug metab dispos. 2001 apr;29(4 pt 1):389-93.[2]. roberti m1, pizzirani d, simoni d, et al. synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. j med chem. 2003 jul 31;46(16):3546-54.[3]. roupe ka1, helms gl, halls sc, et al. preparative enzymatic synthesis and hplc analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. j pharm pharm sci. 2005 aug 22;8(3):374-86. |
| rhapontigenin Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye