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| 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Basic information |
| Product Name: | 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID | | Synonyms: | 3,6-dichloro-2-benzothiophenecarboxylic acid;3,6-dichlorobenzothiophene-2-carboxylic acid;BT2;JR-6478, 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid, 97%;Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-;3,6-Dichloro-1-benzothiophene-2-carboxylicaci;3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXY | | CAS: | 34576-94-8 | | MF: | C9H4Cl2O2S | | MW: | 247.1 | | EINECS: | | Product Categories: | | Mol File: | 34576-94-8.mol |
| 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Chemical Properties |
| Boiling point | 426.4±40.0 °C(Predicted) | | density | 1.653±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to at least 20 mg/ml) | | pka | 2.09±0.30(Predicted) | | form | solid | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Usage And Synthesis |
| Description | 3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO). | | References | 1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583
2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15 |
| 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
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![3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID](/img/34576-94-8.jpg "3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID")
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