Methyl 3-amino-4-methylthiophene-2-carboxylate

CAS No.：85006-31-1

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Methyl 3-amino-4-methylthiophene-2-carboxylate Basic information

Product Name:	Methyl 3-amino-4-methylthiophene-2-carboxylate
Synonyms:	M3A4MT2C;METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLATE;Methyl 3-amino-4-methyl-2-thenoate;METHYL 3-AMINO-4-METHYL-2-THIOPHENECARBOXYLATE;LABOTEST-BB LT00453517;3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER;3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER
CAS:	85006-31-1
MF:	C7H9NO2S
MW:	171.22
EINECS:	285-060-8
Product Categories:	Thiophenes & Benzothiophenes;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Thiophenes;Esters;Thiophenes & Benzothiophenes;Thiophene&Benzothiophene;Organic acids;API intermediates;Thiophen
Mol File:	85006-31-1.mol

Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties

Melting point	85-88 °C (lit.)
Boiling point	318.6±37.0 °C(Predicted)
density	1.264±0.06 g/cm3(Predicted)
Fp	>100°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	1.71±0.10(Predicted)
form	Solid
color	Pale Yellow
Water Solubility	1g/L at 35℃
BRN	973196
InChIKey	YICRPERKKBDRSP-UHFFFAOYSA-N
LogP	1.28
CAS DataBase Reference	85006-31-1(CAS DataBase Reference)
NIST Chemistry Reference	Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-22
WGK Germany	2
Hazard Note	Irritant
HS Code	29349990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Methyl 3-amino-4-methylthiophene-2-carboxylate Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.
Application	methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine. 7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Methyl 3-amino-4-methylthiophene-2-carboxylate Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydride-->Hydroxylamine hydrochloride-->Methyl methacrylate-->Methyl thioglycolate-->Methyl 2-Methyl-3-Oxo-Tetrahydrothiophene-2-Carbonate-->4-METHYL-3-AMINO-2-(METHOXYCARBONYL)-4,5-DIHYDROTHIOPHENE
Preparation Products	4-Chlorothieno[3,2-d]pyri...-->METHYL 3-CHLORO-4-METHYLTHIOPHENE-2-CARBOXYLATE

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