NU1025

CAS No.：90417-38-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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NU1025 Basic information

Product Name:	NU1025
Synonyms:	NU1025;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem;NU 1025;NU 1025;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-Hydroxy-2-methylquinazoline-4-one ,97%;8-hydroxy-2-methyl-1H-quinazolin-4-one
CAS:	90417-38-2
MF:	C9H8N2O2
MW:	176.17
EINECS:
Product Categories:	All Inhibitors;Inhibitors;Aromatics
Mol File:	90417-38-2.mol

NU1025 Chemical Properties

Melting point	253-258°C
density	1.42
storage temp.	−20°C
solubility	DMSO: 35 mg/mL, soluble
form	solid
color	off-white
CAS DataBase Reference	90417-38-2

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	26
WGK Germany	3
HS Code	29335990

MSDS Information

Provider	Language
SigmaAldrich	English

NU1025 Usage And Synthesis

Description	NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC₅₀ = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.
Chemical Properties	Off-White to Pale Yellow Solid
Uses	NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]
Uses	A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively
Uses	A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
Definition	ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Biological Activity	Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

NU1025 Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Methanol-->Tetrahydrofuran-->N,N-Dimethylformamide-->Thionyl chloride-->Magnesium sulfate-->Ammonia-->Pyridine-->Nitrogen-->Isopropyl alcohol-->Hydrogen-->Acetyl chloride-->Ethyl acetoacetate-->2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE-->Boron tribromide-->3-METHOXY-2-NITROBENZOIC ACID

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