Other grades of this product :
| Product Name: | NU1025 | | Synonyms: | NU1025;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem;NU 1025;NU 1025;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-Hydroxy-2-methylquinazoline-4-one ,97%;8-hydroxy-2-methyl-1H-quinazolin-4-one | | CAS: | 90417-38-2 | | MF: | C9H8N2O2 | | MW: | 176.17 | | EINECS: | | Product Categories: | All Inhibitors;Inhibitors;Aromatics | | Mol File: | 90417-38-2.mol |
| NU1025 Chemical Properties |
| Melting point | 253-258°C | | density | 1.42 | | storage temp. | −20°C | | solubility | DMSO: 35 mg/mL, soluble | | form | solid | | color | off-white | | CAS DataBase Reference | 90417-38-2 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 29335990 |
| NU1025 Usage And Synthesis |
| Description | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes. | | Chemical Properties | Off-White to Pale Yellow Solid | | Uses | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical] | | Uses | A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively | | Uses | A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively. | | Definition | ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase. | | Biological Activity | Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively. |
| NU1025 Preparation Products And Raw materials |
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