5-Bromoindole-2-carboxylic acid

5-Bromoindole-2-carboxylic acid
  • CAS No.:7254-19-5
Other grades of this product :
5-Bromoindole-2-carboxylic acid Basic information
Product Name:5-Bromoindole-2-carboxylic acid
Synonyms:5-BROMO-1H-INDOLE-2-CARBOXYLIC ACID;5-BROMO-2-INDOLECARBOXYLIC ACID;5-BROMOINDOLE-2-CARBOXYLIC ACID;AKOS JY2082545;1H-INDOLE-2-CARBOXYLIC ACID, 5-BROMO-;5-bromoindole-2-carboxylicacid5-Bromoindole-2-carboxylicacid;5-Bromoindole-2-carboxylic acid ,98%;5-BroMo-1H-indol-2-carboxylic acid
CAS:7254-19-5
MF:C9H6BrNO2
MW:240.05
EINECS:
Product Categories:Heterocycles series;Indole/indoline/oxindole;Indole and Indoline;Indoles and derivatives;pharmacetical;Organic acids;Indoles;Indole;Halogenated Heterocycles;Heterocyclic Building Blocks;IndolesBuilding Blocks;Pharmaceutical Intermediates;Building Blocks;C7 to C10;C7 to C9;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
Mol File:7254-19-5.mol
5-Bromoindole-2-carboxylic acid Chemical Properties
Melting point 287-288
Boiling point 470.9±25.0 °C(Predicted)
density 1.838±0.06 g/cm3(Predicted)
storage temp. -20°C
form Solid
pka4.25±0.30(Predicted)
color White to Light yellow to Light orange
CAS DataBase Reference7254-19-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-36/37/39
WGK Germany 3
HazardClass IRRITANT
HS Code 29339980
MSDS Information
ProviderLanguage
SigmaAldrich English
5-Bromoindole-2-carboxylic acid Usage And Synthesis
Uses5-Bromoindole-2-carboxylic acid,Reactant involved in studies of biologically active molecules including:Discovery of indole inhibitors of MMP-13 for treatment of arthritic diseases1;Synthesis of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors2 ;cis-Diaminocyclohexane derivatives prepared for use as factor Xa inhibitors3 ;Synthesis of tubulin polymerization inhibitors and cancer cell growth inhibitors4 ;Preparation of dual PPARγ/δ agonists5;Synthesis of chemical probes to examine the role of hFPRL1 receptor .
UsesReactant involved in studies of biologically active molecules including:
  • Discovery of indole inhibitors of MMP-13 for treatment of arthritic diseases
  • Synthesis of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors
  • cis-Diaminocyclohexane derivatives prepared for use as factor Xa inhibitors
  • Synthesis of tubulin polymerization inhibitors and cancer cell growth inhibitors
  • Preparation of dual PPARγ/δ agonists
  • Synthesis of chemical probes to examine the role of hFPRL1 receptor in inflammation
5-Bromoindole-2-carboxylic acid Preparation Products And Raw materials
Raw materialsEthanol-->Polyphosphoric acid-->Ethyl pyruvate-->Lithium hydroxide-->4-BROMOPHENYLHYDRAZINE HYDROCHLORIDE
Preparation Products2-(Ethoxycarbonyl)-5-bromo-indole-->5-Bromoindole-2-carboxylic acid methyl ester

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