1-Methyl-L-histidine

CAS No.：332-80-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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1-Methyl-L-histidine Basic information

Product Name:	1-Methyl-L-histidine
Synonyms:	METHYLHISTIDINE, L-1-;METHYLHISTIDINE, L-3-;1-METHYL-L-HISTIDINE;1-METHYLHISTIDINE;3-(1-METHYLIMIDAZOL-4-YL)-L-ALANINE;3-(1-METHYLIMIDAZOL-5-YL)-L-ALANINE;1-Methyl-L-histidine >=98.0% (TLC);1-N-Methyl-L-histidine
CAS:	332-80-9
MF:	C7H11N3O2
MW:	169.18
EINECS:	206-368-0
Product Categories:	Pharmaceutical Raw Materials;Histidine [His, H];Amino Acids and Derivatives;Amino acids methyl、ethyl、t-butyl series;Amino Acids & Derivatives;Heterocycles;Inhibitors
Mol File:	332-80-9.mol

1-Methyl-L-histidine Chemical Properties

Melting point	~240 °C (dec.) (lit.)
alpha	-24 º (c=2% in H2O)
Boiling point	298.47°C (rough estimate)
density	1.2509 (rough estimate)
refractive index	1.5950 (estimate)
storage temp.	2-8°C(protect from light)
solubility	Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
pka	1.69(at 25℃)
color	Off-White to Pale Beige
optical activity	[α]20/D 24±1°, c = 2% in H2O
BRN	9727
Stability:	Hygroscopic
CAS DataBase Reference	332-80-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-24/25-22
WGK Germany	3
HS Code	29332900

MSDS Information

Provider	Language
SigmaAldrich	English

1-Methyl-L-histidine Usage And Synthesis

Chemical Properties	Beige powder
Uses	The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent developm ent of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
Uses	The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

1-Methyl-L-histidine Preparation Products And Raw materials

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