6-Hydroxy-1-tetralone

6-Hydroxy-1-tetralone
  • CAS No.:3470-50-6
Other grades of this product :
6-Hydroxy-1-tetralone Basic information
Product Name:6-Hydroxy-1-tetralone
Synonyms:6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone, 98%;6-HYDROXY-1-TETRALONE;6-HYDROXY-1-TETRALONE 98.5%;6-Hydroxy-3,4-dihydronaphthalen-1(2H)-one;6-hydroxyl-1-tetralone;4-dihydro-6-hydroxy-;1(2H)-Naphthalenone, 3,4-dihydro-6-hydroxy-;1-Tetralon-6-ol
CAS:3470-50-6
MF:C10H10O2
MW:162.19
EINECS:
Product Categories:Benzocycles;Alcohols and Derivatives;Carbonyl Compounds
Mol File:3470-50-6.mol
6-Hydroxy-1-tetralone Chemical Properties
Melting point 154-157 °C(lit.)
Boiling point 358.0±31.0 °C(Predicted)
density 1.236±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka8.22±0.20(Predicted)
form Crystalline Powder
color Off-white to brown
InChIKeyFNSQPQKPPGALFA-UHFFFAOYSA-N
CAS DataBase Reference3470-50-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29145090
MSDS Information
ProviderLanguage
SigmaAldrich English
6-Hydroxy-1-tetralone Usage And Synthesis
Chemical Propertiesgray powder
Uses6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines.
Uses6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) may be used in the synthesis of:
  • 5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone
  • 6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone
  • 6-(3-(piperidin-1-yl)propoxy)-1-tetralone
Synthesis Reference(s)Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527vJournal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052
General Description6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) can be prepared by the demethylation of 6-methoxy-3,4-dihydro-1(2H)-naphthalenone. It participates in the synthesis of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. Its pKa value has been reported to be 7.74.
6-Hydroxy-1-tetralone Preparation Products And Raw materials
Raw materials7-Hydroxy-1-tetralone
Preparation Products6-CYANO-1-TETRALONE-->6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one

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