4-Chlorophenylboronic acid

4-Chlorophenylboronic acid
  • CAS No.:1679-18-1
Other grades of this product :
4-Chlorophenylboronic acid Basic information
Product Name:4-Chlorophenylboronic acid
Synonyms:4-Chlorophenylboronic acid,97%;4-Chlorophenylboronic acid, May contain varying amounts of anhydride, 97%;4-Chlorophenylboronic acid,4-Chlorobenzeneboronic acid;p-chlorophenylboronic aci;(4-chlorophenyl)boronic acid(SALTDATA: 0.7H2O);4-Chlorophenylboronic acid, 97% 5GR;NSC 25408;BORONIC ACID, (4-CHLOROPHENYL)-;P-CHLOROBENZENEBORONIC ACID;
CAS:1679-18-1
MF:C6H6BClO2
MW:156.37
EINECS:216-845-5
Product Categories:blocks;BoronicAcids;Fluorin-contained phenyl boronic acid series;Boronic Acid series;Heterocyclic Compounds;Boronic Acid;Substituted Boronic Acids;Boric acid;Boronic acids;Aryl;Organoborons;B (Classes of Boron Compounds);organic or inorganic borate;Boronate Ester;Potassium Trifluoroborate
Mol File:1679-18-1.mol
4-Chlorophenylboronic acid Chemical Properties
Melting point 284-289 °C(lit.)
Boiling point 295.4±42.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO
pka8.39±0.10(Predicted)
form Crystalline Powder
color Off-white to beige
Water Solubility 2.5 g/100 mL
BRN 2936346
InChIKeyCAYQIZIAYYNFCS-UHFFFAOYSA-N
CAS DataBase Reference1679-18-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 36-37/39-26
WGK Germany 3
RTECS CY8950000
TSCA No
HazardClass IRRITANT
HS Code 29319090
MSDS Information
ProviderLanguage
4-Chlorophenylboronic acid English
SigmaAldrich English
ACROS English
ALFA English
4-Chlorophenylboronic acid Usage And Synthesis
Chemical Propertiesoff-white to beige crystalline powder
Usessuzuki reaction
Uses4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.
Uses4-Chlorophenylboronic acid can be used as a reactant in:
  • Palladium-catalyzed direct arylation.
  • Cyclopalladation.
  • Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation.
  • Copper-mediated ligandless aerobic fluoroalkylation.
  • Pd-catalyzed arylative cyclization.
  • Ruthenium catalyzed direct arylation.
  • Ligand-free copper-catalyzed coupling reactions.
  • Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions.
It can also be used to prepare:
  • Substituted diarylmethylidenefluorenes via Suzuki coupling reaction.
  • Baclofen lactam by Suzuki coupling of a pyrrolinyl tosylate, followed by hydrogenation reaction.
  • Palladium(II) thiocarboxamide complexes as Suzuki coupling catalysts.
  • Biaryls by Suzuki reactions of aryl chlorides, bromides, and iodides with arylboronic acids.

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