BISPYRAZOLONE

CAS No.：7477-67-0

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BISPYRAZOLONE Basic information

Product Name:	BISPYRAZOLONE
Synonyms:	BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE);BIS(1-PHENYL-3-METHYL-5-PYRAZOLONE);BISPYRAZOLONE;LABOTEST-BB LT00008461;4,4'-BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE);4,4'-BIS(1-PHENYL-3-METHYL-5-PYRAZOLONE);3,3-DIMETHYL-1,1-DIPHENYL-(4,4-BI-2-PYRAZOLINE)-5,5-DIONE;3,3'-DIMETHYL-1,1'-DIPHENYL-[4,4'-BI-2-PYRAZOLINE]-5,5'-DIONE
CAS:	7477-67-0
MF:	C20H18N4O2
MW:	346.38
EINECS:	231-282-5
Product Categories:	Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds
Mol File:	7477-67-0.mol

BISPYRAZOLONE Chemical Properties

Melting point	355 °C
Boiling point	481.12°C (rough estimate)
density	1.31
refractive index	1.6620 (estimate)
storage temp.	Refrigerator
solubility	formic acid: 50 mg/mL, clear, yellow
pka	2.15±0.70(Predicted)
form	crystalline
color	tan
BRN	572787
CAS DataBase Reference	7477-67-0(CAS DataBase Reference)
EPA Substance Registry System	[4,4'-Bi-3H-pyrazole]-3,3'-dione, 2,2',4,4'-tetrahydro-5,5'-dimethyl-2,2'-diphenyl- (7477-67-0)

Safety Information

Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
WGK Germany	3
TSCA	Yes
HS Code	29331990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

BISPYRAZOLONE Usage And Synthesis

Chemical Properties	off-white to cream-yellowish crystalline powder
Uses	Bispyrazolone is an impurity of Edaravone (E335000).
Uses	It is applied as a reagent for the detection and determination of cyanide. It is also used in an experimental procedure, done in order to remove linamarin in starch from cassava roots, by using plant cell wall-degrading enzymes, xylanase and cellulase. It was also used for spectrophotometric determination and quantization of urea in urine samples. It is also used in assay of cyanogenic compounds and determination of ammonia.

BISPYRAZOLONE Preparation Products And Raw materials

Raw materials	Acetic acid-->N-Bromosuccinimide-->Ethyl acetoacetate-->Sodium acetate trihydrate-->Phenylhydrazine-->1H-Pyrazol-5-ol, 3-methyl-4-nitroso-1-phenyl--->4-bromo-3-methyl-1-phenyl-pyrazolin-5-one-->Edaravone-->1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one-->Ethanol-->Selenium dioxide-->5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Preparation Products	4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-1,2-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one

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