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| L-DIHYDROOROTIC ACID Basic information |
| L-DIHYDROOROTIC ACID Chemical Properties |
| Melting point | 254-255 °C (dec.)(lit.) | | Boiling point | 283.16°C (rough estimate) | | density | 1.523 | | refractive index | 1.5090 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) | | pka | 2.82±0.20(Predicted) | | form | Powder | | color | White to off-white | | Water Solubility | Soluble in water (partly), and dimethyl formamide. | | InChIKey | UFIVEPVSAGBUSI-REOHCLBHSA-N | | CAS DataBase Reference | 5988-19-2(CAS DataBase Reference) | | NIST Chemistry Reference | Orotic acid, dihydro-, l-(5988-19-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| L-DIHYDROOROTIC ACID Usage And Synthesis |
| Chemical Properties | White to off-white crystalline powder | | Uses | L-Dihydroorotic acid a metabolite. | | Biochem/physiol Actions | L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors. |
| L-DIHYDROOROTIC ACID Preparation Products And Raw materials |
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