Fluoroacetonitrile

Fluoroacetonitrile
  • CAS No.:503-20-8

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
Other grades of this product :
Fluoroacetonitrile Basic information
Product Name:Fluoroacetonitrile
Synonyms:Fluoromethyl cyanide;FLUOROACETONITRILE;Acetonitrile, fluoro-;fluoro-acetonitril;Floroacetonitrile;monofluoroacetonitrile;Fluoroacetonitrile,99%;2-fluoroacetonitrile
CAS:503-20-8
MF:C2H2FN
MW:59.04
EINECS:
Product Categories:C1 to C5;Cyanides/Nitriles;Nitrogen Compounds
Mol File:503-20-8.mol
Fluoroacetonitrile Chemical Properties
Melting point -13 °C
Boiling point 79-80 °C (lit.)
density 1.061 g/mL at 25 °C (lit.)
refractive index 1.333
Fp 7°F
Water Solubility Slightly soluble in water
form clear liquid
color Colorless to Almost colorless
CAS DataBase Reference503-20-8(CAS DataBase Reference)
NIST Chemistry ReferenceFluoroacetonitrile(503-20-8)
Safety Information
Hazard Codes F;T,T,F
Risk Statements 11-23/24/25-36/37/38
Safety Statements 16-26-27-36/37/39-45
RIDADR UN 3273
WGK Germany 3
RTECS AM0175000
HazardClass 3.1
PackingGroup II
HS Code 2926907090
MSDS Information
Fluoroacetonitrile Usage And Synthesis
UsesFluoroacetonitrile is a water disinfectant byproduct that showed weak inhibition of rat hepatic glutathione S-transferases in vitro. Fluoroacetonitrile is also a reagent in the preparation of the PAD4 inhibitor F-Amidine.
UsesFluoroacetonitrile has been used in preparation of:
  • 2-fluoromethyl-4,4,6-trimethyl-1,3-oxazine
  • α-fluorinated acetophenone
  • 2-amino-2-fluoromethyl-3-pentenenitrile, a key intermediate in the synthesis of 2,5-diamino-2-fluoromethyl-3(E)-pentenoic acid
Synthesis Reference(s)Journal of Medicinal Chemistry, 26, p. 1551, 1983 DOI: 10.1021/jm00365a002
Fluoroacetonitrile Preparation Products And Raw materials
Preparation Products2'-FLUOROACETOPHENONE-->FLUOROACETAMIDE

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