2-Amino-5-methylpyridine

CAS No.：1603-41-4

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2-Amino-5-methylpyridine Basic information

Product Name:	2-Amino-5-methylpyridine
Synonyms:	5-Methyl-2-aminopyridine;5-methyl-2-pyridinamin;5-Methyl-2-pyridinamine;5-Methyl-2-pyridylamine dine;6-Amino-3-picoline 2-Amino-5-picoline 5-Methyl-2-pyridylamine;6-Amino-3-picoline, 5-Methylpyridin-2-amine;2-AMino-5-picoline, 99% 10GR;6-amino-3-picolin
CAS:	1603-41-4
MF:	C6H8N2
MW:	108.14
EINECS:	216-503-5
Product Categories:	Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;Heterocycle-Pyridine series;amine;VARIOUSAMINE;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Amines;Pyridines;Aromatics;Heterocycles;Pyridines derivates;bc0001
Mol File:	1603-41-4.mol

2-Amino-5-methylpyridine Chemical Properties

Melting point	76-77 °C(lit.)
Boiling point	227 °C(lit.)
density	227
vapor pressure	3.706Pa at 25℃
refractive index	1,524-1,528
Fp	118°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1000g/l
form	Crystalline Powder, Crystals or Flakes
pka	pK1: 7.22(+1) (25°C)
color	White to light yellow
Sensitive	Hygroscopic
BRN	107050
InChIKey	CMBSSVKZOPZBKW-UHFFFAOYSA-N
LogP	1.08
CAS DataBase Reference	1603-41-4(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridinamine, 5-methyl-(1603-41-4)
EPA Substance Registry System	6-Amino-3-picoline (1603-41-4)

Safety Information

Hazard Codes	T,Xi
Risk Statements	23/24/25-36/37/38-25
Safety Statements	26-36/37/39-45-37/39-28A
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	TJ5141000
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29333999
Toxicity	LD50 orl-rat: 200 mg/kg 85JCAE -,841,86

MSDS Information

Provider	Language
5-Methyl-2-pyridylamine	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Amino-5-methylpyridine Usage And Synthesis

Chemical Properties	light yellow crystalline flakes
Uses	Intermediate.
Safety Profile	Poison by ingestion,subcutaneous, and skin contact routes. When heated todecomposition it emits toxic vapors of NOx.
Purification Methods	Crystallise it from acetone. [Beilstein 22/9 V 289.]

2-Amino-5-methylpyridine Preparation Products And Raw materials

Raw materials

Hydrogen bromide-->Trimethylamine-->Chloromethane-->Trimethylamine hydrochloride-->3-Picoline-N-oxide-->5-Methylpyridine

Preparation Products

2-Chloro-5-methylpyridine-->Ethyl 6-aminonicotinate-->(5-METHOXYMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER-->6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACID-->3-AMINO-2-CHLORO-5-PICOLINE-->6-Aminonicotinic acid-->(6-AMINO-3-PYRIDINYL)METHANOL-->TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL]CARBAMATE-->6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID-->METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE-->Methyl 6-aminonicotinate-->Nalidixic acid-->2-Chloro-5-methyl-3-nitropyridine-->6-AMINONICOTINOHYDRAZIDE-->2-BROMO-3-NITRO-5-METHYL PYRIDINE-->2,3-Dichloro-5-(trifluoromethyl)pyridine-->2-Amino-3-bromo-5-methylpyridine-->2-Hydroxy-5-methyl-3-nitropyridine-->2-FLUOROPYRIDINE-5-CARBONYL CHLORIDE-->METHYL 6-(ACETYLAMINO)NICOTINATE-->6-Fluoronicotinic acid-->2-ACETYLAMINO-3-BROMO-5-METHYLPYRIDINE-->2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID-->2-AMINO-3-NITRO-5-PICOLINE-->2-Fluoro-5-methylpyridine-->2-ACETAMIDO-5-PICOLINE

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