2-Amino-5-bromobenzotrifluoride

CAS No.：445-02-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Amino-5-bromobenzotrifluoride Basic information

Product Name:	2-Amino-5-bromobenzotrifluoride
Synonyms:	2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE;2-AMINO-5-BROMOBENZOTRIFLUORIDE;4-BROMO-2-(TRIFLUOROMETHYL)ANILINE;4-Bromo-alpha,alpha,alpha-trifluoro-o-toluidine;4-bromo-2-(trifluoromethyl)-benzenamin;2-Amino-5-bromobenzotrifluoride 98%;2-Amino-5-bromobenzotrifluoride98%;4-bromo-2-(Trilfuoromethyl)aniline
CAS:	445-02-3
MF:	C7H5BrF3N
MW:	240.02
EINECS:	207-150-8
Product Categories:	Amines;C7;Aromatic Halides (substituted);Aniline;Benzotrifluoride Series;Nitrogen Compounds;Trifluoromethylbenzene serise
Mol File:	445-02-3.mol

2-Amino-5-bromobenzotrifluoride Chemical Properties

Melting point	84～86℃/5mm
Boiling point	84-86 °C5 mm Hg(lit.)
density	1.71 g/mL at 25 °C(lit.)
refractive index	n20/D 1.532(lit.)
Fp	225 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	0.76±0.10(Predicted)
form	clear liquid
color	Light yellow to Yellow to Orange
Specific Gravity	1.71
BRN	2211504
InChIKey	PHXGKHTWEOPCEW-UHFFFAOYSA-N
CAS DataBase Reference	445-02-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 4-bromo-2-(trifluoromethyl)-(445-02-3)
EPA Substance Registry System	4-Bromo-2-(trifluoromethyl)aniline (445-02-3)

Safety Information

Hazard Codes	Xn,Xi,C
Risk Statements	20/21/22-36/37/38-34
Safety Statements	26-36-36/37/39-45-27
WGK Germany	3
Hazard Note	Irritant
TSCA	T
HazardClass	6.1
HS Code	29214300

MSDS Information

Provider	Language
2-Amino-5-bromobenzotrifluoride	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Amino-5-bromobenzotrifluoride Usage And Synthesis

Chemical Properties	Clear yellow liquid
Uses	4-Bromo-2-(trifluoromethyl)aniline has been used in the preparation of 2,5-dibromo-(trifluoromethyl)benzene and 5-bromo-2-iodo-(trifluoromethyl)benzene.
Uses	2-Amino-5-bromobenzotrifluoride is a reagent used for the synthesis of α-aminophosphonate which exhibits moderate antitumor activity.

2-Amino-5-bromobenzotrifluoride Preparation Products And Raw materials

Raw materials	N-(4-bromophenyl)picolinamide-->BROMOTRIFLUOROMETHANE-->5-Bromo-2-nitrobenzotrifluoride-->3-Aminobenzotrifluoride-->4-Bromoaniline-->1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one-->Sodium trifluoromethanesulfinate-->Trifluoromethyl iodide-->Benzotrifluoride-->3-Bromobenzotrifluoride-->2-Aminobenzotrifluoride
Preparation Products	5-BROMO-2-IODOBENZOTRIFLUORIDE

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