Tetraisopropyl methylenediphosphonate

CAS No.：1660-95-3

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Tetraisopropyl methylenediphosphonate Basic information

Product Name:	Tetraisopropyl methylenediphosphonate
Synonyms:	METHYLENEDIPHOSPHONIC ACID TETRAISOPROPYL ESTER;TETRAISOPROPYL(METHYLENE)BISPHOSPHONATE;TETRAISOPROPYL METHYLENEDIPHOSPHONATE;Phosphonic acid, methylenebis-, tetrakis(1-methylethyl) ester;Phosphonic acid, methylenedi-, tetraisopropyl ester;phosphonicacid,methylenebis-,tetrakis(1-methylethyl)ester;tetra-i-Propylmethylenediphosphonate;Methanediphosphonic acid tetraisopropyl ester
CAS:	1660-95-3
MF:	C13H30O6P2
MW:	344.32
EINECS:	216-765-0
Product Categories:	Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds
Mol File:	1660-95-3.mol

Tetraisopropyl methylenediphosphonate Chemical Properties

Boiling point	155 °C/0.5 mmHg (lit.)
density	1.08 g/mL at 25 °C (lit.)
vapor pressure	0.017Pa at 20℃
refractive index	n20/D 1.431(lit.)
Fp	320 °F
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	neat
Specific Gravity	1.080
color	Clear Colourless to Yellow
Water Solubility	Insoluble in water.
BRN	1080180
InChIKey	FKHXXJRKGVDPQP-UHFFFAOYSA-N
LogP	1.3 at 20℃
CAS DataBase Reference	1660-95-3(CAS DataBase Reference)
NIST Chemistry Reference	Tetraisopropyl methylenediphosphonate(1660-95-3)
EPA Substance Registry System	Phosphonic acid, methylenebis-, tetrakis(1-methylethyl) ester (1660-95-3)

Safety Information

Hazard Codes	Xi
Risk Statements	41
Safety Statements	26-36-39
WGK Germany	3
TSCA	Yes
HS Code	29319090

MSDS Information

Provider	Language
Tetraisopropyl methylenediphosphonate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Tetraisopropyl methylenediphosphonate Usage And Synthesis

Chemical Properties	Clear colorless to slightly yellow liquid
Uses	Tetraisopropyl Methylenediphosphonate is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents. Also used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase.
Uses	Tetraisopropyl methylenediphosphonate [T(iPr)MDP] forms a synergistic mixture with hydrogen dicarbollylcobaltate in nitrobenzene which was used in the extraction of europium and americium.It may be used in the synthesis of the following: tetraisopropyl ethenylidenebisphosphonate. tetraisopropyl 4-acetylthiobutane-1,1-diphosphonate tetraisopropyl 2-(3,5-bis(bromomethyl)phenyl)ethane-1,1-diphosphonate
General Description	Tetraisopropyl methylenediphosphonate (IPCP) is a tetraisopropyl ester of methylenediphosphonic acid. It is an electroneutral ligand, reported to be synthesized from triisopropyl phosphate. Powder electron paramagnetic resonance (EPR) studies of tris complexes of Cu(II) complexes with IPCP has been analyzed.

Tetraisopropyl methylenediphosphonate Preparation Products And Raw materials

Raw materials	1-METHYLETHYLPHOSPHONICACIDBIS(1-METHYLETHYL)ESTER-->Phosphorous acid, bis(1-methylethyl) ester-->TRIISOPROPYL PHOSPHATE
Preparation Products	METHYLENEDIPHOSPHONIC ACID-->METHYLENEBIS(PHOSPHONIC DICHLORIDE)-->TETRAISOPROPYL DICHLOROMETHYLENE DIPHOSPHONATE

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