Cremophor EL

CAS No.：61791-12-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Cremophor EL Basic information

Product Name:	Cremophor EL
Synonyms:	polyoxyethylene castor oil;POLYOXYETHYLENE(10) CASTOR OIL;POLYETHYLENEGLYCOL CASTOR OIL;Castoroil,ethyleneglycolpolymer;Castoroil,ethyleneoxidereactionproduct;Castoroil,polyethoxylated;castoroilpolyoxyethyleneether;polyethoxylatedcastoroil
CAS:	61791-12-6
MF:	NULL
MW:	0
EINECS:	500-151-7
Product Categories:	Detergents;Detergents A to ZDetergents;Non-Ionic
Mol File:	Mol File

Cremophor EL Chemical Properties

Boiling point	232.6℃[at 101 325 Pa]
density	1.05 g/mL at 20 °C
vapor pressure	0Pa at 25℃
Fp	257℃
storage temp.	REFRIGERATOR (+4C)
form	Viscous Liquid
pka	0[at 20 ℃]
color	Clear yellow
PH	5.0-7.0 (1g/10 mL in H2O)
Water Solubility	24.11mg/L at 25℃
Stability:	Stable. Incompatible with storng oxidizing agents.
LogP	4.297 at 25℃
CAS DataBase Reference	61791-12-6
EPA Substance Registry System	Ethoxylated castor oil (61791-12-6)

Safety Information

WGK Germany	1
RTECS	GO5661000
HS Code	15153090

MSDS Information

Provider	Language
SigmaAldrich	English

Cremophor EL Usage And Synthesis

Chemical Properties	light yellow liquid
Uses	Polyoxyl 35 Castor Oil is a triglyceride fatty acid which has the potential to repel insects and promote plant growth.
Uses	Kolliphor^? EL has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation. It has been used as a vehicle for drug/stimulant delivery in cells.
General Description	Kolliphor^? EL is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour.
Flammability and Explosibility	Notclassified
Biochem/physiol Actions	Kolliphor? EL is used in lipid-based formulations for drugs and solubilization of cosmetics. Kolliphor EL is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds. Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.

Cremophor EL Preparation Products And Raw materials

Raw materials	Hydrogen peroxide-->Castor oil-->castor oil polyoxyethylene (90) ether
Preparation Products	pesticide emulsifier 0203B-->pesticide emulsifier 0206-->Pesticide emulsifier 0207-->Pesticide emulsifier S-118-->pesticide emulsifier 0208-->pesticide emulsifier 0206B-->pesticide emulsifier 0205

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