Other grades of this product :
| Palifosfamide Basic information |
| Product Name: | Palifosfamide | | Synonyms: | Ifosforamide mustard;Ipam;N,N'-Di-(2-chloroethyl)phosphorodiamidic acid;N,N'-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDATE;Isophosphamide mustard;palifosfamide;N,N'-Bis(2-chloroethyl)phosphorodiamidic acid;ZIO-201, >98% | | CAS: | 31645-39-3 | | MF: | C4H11Cl2N2O2P | | MW: | 221.02 | | EINECS: | | Product Categories: | | Mol File: | 31645-39-3.mol |
| Palifosfamide Chemical Properties |
| Melting point | 106-107 ºC | | Boiling point | 341.5±52.0 °C(Predicted) | | density | 1.411 | | solubility | ≥22.1 mg/mL in DMSO; insoluble in EtOH; ≥19.4 mg/mL in H2O with gentle warming and ultrasonic | | pka | 0.79±0.50(Predicted) | | CAS DataBase Reference | 31645-39-3 |
| Palifosfamide Usage And Synthesis |
| Description | Palifosfamide is an active metabolite of the DNA alkylating agent ifosfamide . Palifosfamide is formed through hydroxylation of ifosfamide by various hepatic cytochrome P450 (CYP) isoforms. It is cytotoxic to L1210 and CCRF-CEM cancer cells when used at a concentration of 100 μM. Palifosfamide (100 mg/kg per day) reduces tumor growth in murine Lewis lung carcinoma and L1210 leukemia models, as well as a rat Yoshida ascitic sarcoma model. |
| Palifosfamide Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye