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| Dimethocaine Basic information |
| Product Name: | Dimethocaine | | Synonyms: | Dimethocaine;NSC 68927;3-Diethylamino-2,2-dimethylpropyl 4-aminobenzoate;4-Aminobenzoic acid 3-(diethylamino)-2,2-dimethylpropyl ester;3-(Diethylamino)-2,2-dimethyl-1-propanol p-aminobenzoate;Larocaine;p-Aminobenzoic acid 3-(diethylamino)-2,2-dimethylpropyl;p-Aminobenzoic acid 3-(diethylamino)-2,2-dimethylpropyl ester | | CAS: | 94-15-5 | | MF: | C16H26N2O2 | | MW: | 278.39 | | EINECS: | 1592732-453-0 | | Product Categories: | chemical research;medicine grade;pharmaceutical intermediate;94-15-5 | | Mol File: | 94-15-5.mol |
| Dimethocaine Chemical Properties |
| Melting point | 53.0 to 57.0 °C | | Boiling point | 421.21°C (rough estimate) | | density | 1.035 | | refractive index | 1.5290 (estimate) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 10.08±0.25(Predicted) | | color | Pale Orange to Light Orange | | Merck | 14,3221 | | InChI | InChI=1S/C16H26N2O2/c1-5-18(6-2)11-16(3,4)12-20-15(19)13-7-9-14(17)10-8-13/h7-10H,5-6,11-12,17H2,1-4H3 | | InChIKey | OWQIUQKMMPDHQQ-UHFFFAOYSA-N | | SMILES | C(OC(=O)C1=CC=C(N)C=C1)C(CN(CC)CC)(C)C | | CAS DataBase Reference | 94-15-5 |
| Dimethocaine Usage And Synthesis |
| Description | Dimethocaine, also known as DMC or larocaine, is a compound with stimulating effects similar to those of cocaine. It was used in the 1930s as a local anesthetic in dentistry and ophthalmology. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the category “synthetic cocaine derivatives”. The structure of dimethocaine, being a 4-aminobenzoic acid ester, resembles that of procaine. | | Chemical Properties | Dimethocaine is a yellow chrystalline powder. It is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. | | Uses | Dimethocaine is a local anesthetic with stimulatory properties that is half the potency of cocaine. It is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation.Its positive effects are euphoria, stimulation, increased talkativeness and mood lift.However, because dimethocaine acts similar as cocaine, it has comparable negative side effects. These side effects include: tachycardia, difficulty with breathing, pain on the chest, vasoconstriction, insomnia, paranoia and anxiety. | | Definition | ChEBI: Dimethocaine is a benzoate ester. It is derivate from cocaine, it is not a part of the organic alkaloid mix coming from a coca plant. It is very popular research chemical, mainly used as local anesthetic, but also the stimulant qualities appeared to be shown immediately. | | Biological Activity | Dimethocaine is a local anesthetic that, because of its similarity in action to cocaine, has potential for abuse. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1.2 μM comparable to that of cocaine (IC50 = 0.7 μM). As a result, dimethocaine dose-dependently substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys. This product is intended for forensic and research purposes. |
| Dimethocaine Preparation Products And Raw materials |
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