Di-tert-Butyl malonate

Di-tert-Butyl malonate
  • CAS No.:541-16-2

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
Other grades of this product :
Di-tert-Butyl malonate Basic information
Product Name:Di-tert-Butyl malonate
Synonyms:Propanedioic acid, bis(1,1-dimethylethyl) ester;propanedioicacid,bis(1,1-dimethylethyl)ester;Di-tert-butyl malonate stab. with potassium carbonate;Di-tert-Butyl malote;1,3-di-tert-butyl propanedioate;DI-TERT-BUTYL MALONATE;DI-T-BUTYL MALONATE;bis(1,1-dimethylethyl) malonate
CAS:541-16-2
MF:C11H20O4
MW:216.27
EINECS:208-769-6
Product Categories:Building Blocks;C10 to C11;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Carbonyl Compounds;Esters;bc0001
Mol File:541-16-2.mol
Di-tert-Butyl malonate Chemical Properties
Melting point -7--6 °C (lit.)
Boiling point 110-111 °C/22 mmHg (lit.)
density 0.966 g/mL at 25 °C (lit.)
refractive index n20/D 1.418(lit.)
Fp 88 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Ethyl Acetate
pka11.87±0.46(Predicted)
form Liquid
color Clear colorless to slightly yellow
Water Solubility It is hardly soluble in water.
Merck 14,3034
BRN 1781766
InChIKeyCLPHAYNBNTVRDI-UHFFFAOYSA-N
CAS DataBase Reference541-16-2(CAS DataBase Reference)
NIST Chemistry Referencedi-tert-Butyl malonate(541-16-2)
EPA Substance Registry SystemPropanedioic acid, bis(1,1-dimethylethyl) ester (541-16-2)
Safety Information
Risk Statements 36/37/38-24/25
Safety Statements 23-24/25
WGK Germany 3
TSCA Yes
HS Code 29171910
MSDS Information
ProviderLanguage
Malonic acid di-tert-butyl ester English
ACROS English
SigmaAldrich English
ALFA English
Di-tert-Butyl malonate Usage And Synthesis
Chemical Propertiesclear colorless to slightly yellow liquid
UsesIn the preparation of ketones.
UsesDi-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T
UsesDi-tert-butyl malonate was used in total synthesis of (+/?)-actinophyllic acid. It was also employed as precursor for metal-organic chemical vapor deposition of HfO2 and ZrO2 thin films.
Di-tert-Butyl malonate Preparation Products And Raw materials
Preparation ProductsPazufloxacin

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