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| 2-(2-Bromoethyl)-1,3-dioxolane Basic information |
| Product Name: | 2-(2-Bromoethyl)-1,3-dioxolane | | Synonyms: | 2-(2-Bromoethyl)-1,3-dioxolane,3-Bromopropionaldehyde ethylene acetal;2-(2-Bromoethyl)-1,3;2-(2-BroMoethyl)-1,3-dioxolane, 97% 10GR;2KG;2-(2-BroMoethyl)-1,3-dioxolane 96%;2-(2-Bromoethyl)-1,3-dioxolane, 95%, stabilized;2-(2-Bromoethyl)-1,3-dioxolane,97%;2-(2-Bromoethyl)-1,3-dioxolane,96% | | CAS: | 18742-02-4 | | MF: | C5H9BrO2 | | MW: | 181.03 | | EINECS: | 242-551-1 | | Product Categories: | Acetals/Ketals/Ortho Esters;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Pyridines ,Heterocyclic Acids;Miscellaneous;Dioxanes & Dioxolanes;Dioxolanes | | Mol File: | 18742-02-4.mol |
| 2-(2-Bromoethyl)-1,3-dioxolane Chemical Properties |
| Boiling point | 68-70 °C8 mm Hg(lit.) | | density | 1.542 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.479(lit.) | | Fp | 149 °F | | storage temp. | 2-8°C | | form | clear liquid | | Specific Gravity | 1.541.542 | | color | brownish-yellow | | Water Solubility | immiscible | | Sensitive | Light Sensitive | | BRN | 103516 | | InChIKey | GGZQLTVZPOGLCC-UHFFFAOYSA-N | | CAS DataBase Reference | 18742-02-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2-(2-Bromoethyl)-1,3-dioxolane(18742-02-4) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-37/39 | | RIDADR | UN 2810 6.1/PG 3 | | WGK Germany | 2 | | F | 8-9 | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29329990 |
| 2-(2-Bromoethyl)-1,3-dioxolane Usage And Synthesis |
| Chemical Properties | Clear colorless to yellow or brown liquid | | Uses | Alkylating agent for amines,1 dithianes,2 and carboximides,3 and via the Grignard reagent, aldehydes.4 | | Uses | 2-(2-Bromoethyl)-1,3-dioxolane is used as a pharmaceutical intermediate, dioxolanes, acetals, ketals, building blocks, chemical synthesis, organic building blocks and oxygen compounds. 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures. It is also used as flavouring agent. | | General Description | Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride affords the key organotrifluoroborate reagent. | | Purification Methods | Dissolve it in pentane, wash with 5% aqueous NaHCO3, dry (Na2SO4), and evaporate. Distil the residue. [NMR: Büchi & Wüest J Org Chem 34 1122 1969, Kriesat & Gisvold J Pharm Sci 60 1250 1971, Beilstein 19/1 V 69.] |
| 2-(2-Bromoethyl)-1,3-dioxolane Preparation Products And Raw materials |
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