Other grades of this product :
| SCH772984 Basic information |
| Product Name: | SCH772984 | | Synonyms: | SCH772984;SCH772984/SCH-772984;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide SCH772984;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-;SCH772984, >=98%;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide, 98%, a selective inhibitor of ERK1/2 | | CAS: | 942183-80-4 | | MF: | C33H33N9O2 | | MW: | 587.67 | | EINECS: | 1592732-453-0 | | Product Categories: | Inhibitors;api;MAPK | | Mol File: | 942183-80-4.mol |
| SCH772984 Chemical Properties |
| Melting point | >214°C (dec.) | | Boiling point | 857.3±65.0 °C(Predicted) | | density | 1.353±0.06(20.0000℃) | | storage temp. | Refrigerator | | solubility | DMSO (Slightly) | | pka | 12.05±0.40(Predicted) | | form | Solid | | color | Pale Yellow | | CAS DataBase Reference | 942183-80-4 |
| SCH772984 Usage And Synthesis |
| Description | The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 μM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms. | | Uses | SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models. |
| SCH772984 Preparation Products And Raw materials |
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