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| Hydroxypioglitazone Basic information |
| Hydroxypioglitazone Chemical Properties |
| Melting point | 157-1580C | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | CAS DataBase Reference | 146062-44-4 |
| Hydroxypioglitazone Usage And Synthesis |
| Description | Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM). | | Chemical Properties | Off-White Solid | | Uses | A metabolite of Pioglitazone (P471000). |
| Hydroxypioglitazone Preparation Products And Raw materials |
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