Other grades of this product :
| ETOFYLLINE CLOFIBRATE Basic information |
| Product Name: | ETOFYLLINE CLOFIBRATE | | Synonyms: | ETOFYLLINE CLOFIBRATE;1-(7-theophyllinyl)-2-ethyl(2-(p-chlorophenoxy)isobutyrate);1-(theophyllin-7-yl)-aethyl-22-(p-chlorphenoxy)-2-methylpropionat;1-(theophyllin-7-yl)-ethyl-22-(p-chlorophenoxy)-2-methylpropionate;duolip;etofyllinclofibrat;etofyllinclofibrate;ml1024 | | CAS: | 54504-70-0 | | MF: | C19H21ClN4O5 | | MW: | 420.85 | | EINECS: | 259-191-6 | | Product Categories: | API | | Mol File: | 54504-70-0.mol |
| ETOFYLLINE CLOFIBRATE Chemical Properties |
| Melting point | 133-135° | | density | 1.3758 (rough estimate) | | refractive index | 1.6500 (estimate) |
| Toxicity | LD50 in mice, rats, dogs (g/kg): 11.7, 17.0, >10.0 orally (Metz et al.) |
| ETOFYLLINE CLOFIBRATE Usage And Synthesis |
| Originator | Duolip,Merckle,W. Germany,1981 | | Uses | Duolip (L. Merckle, Germany). | | Manufacturing Process | 107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol)
7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They
were heated together for 15 hours in a water separator following the addition
of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute
sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated
in a rotary evaporator.The residue was then crystallized from isopropanol, yielding 58.0 g (55%
yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The
compound had a melting point of 131°C to 132°C. | | Therapeutic Function | Antihyperlipidemic |
| ETOFYLLINE CLOFIBRATE Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye