2-(4-Methylphenyl)propanoic acid

2-(4-Methylphenyl)propanoic acid
  • CAS No.:938-94-3
Other grades of this product :
2-(4-Methylphenyl)propanoic acid Basic information
Product Name:2-(4-Methylphenyl)propanoic acid
Synonyms:2-(p-Tolyl)propionic acidalpha,4-Dimethylphenylacetic acid;2-(4-Methylphenyl)pr;2-(p-Tolyl)propionic acid, 98% 5GR;α-(p-Tolyl)propionic Acid;α,4-DiMethylbenzeneacetic Acid;Ibuprofen IMpurity-D -(EP);Ibuprofen EP Impurity D;5932B+5242:5246
CAS:938-94-3
MF:C10H12O2
MW:164.2
EINECS:627-324-0
Product Categories:Aromatic Propionic Acids;Carboxylic Acids;Phenyls & Phenyl-Het;Carboxylic Acids;Phenyls & Phenyl-Het;Intermediates
Mol File:938-94-3.mol
2-(4-Methylphenyl)propanoic acid Chemical Properties
Melting point 37-42 °C(lit.)
Boiling point 231.67°C (rough estimate)
density 1.0041 (rough estimate)
refractive index 1.518-1.52
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka4.44±0.10(Predicted)
color White to Off-White Low-Melting
BRN 2251315
CAS DataBase Reference938-94-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29163990
MSDS Information
ProviderLanguage
2-(4-Tolyl)propionic acid English
ACROS English
SigmaAldrich English
2-(4-Methylphenyl)propanoic acid Usage And Synthesis
Chemical Propertiesclear yellow liquid after melting
Uses2-(p-Tolyl)propionic acid is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.
Uses2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.
Synthesis Reference(s)Synthesis, p. 231, 1984 DOI: 10.1055/s-1984-30784Tetrahedron Letters, 36, p. 5641, 1995 DOI: 10.1016/0040-4039(95)01035-G
General Descriptionα,4-Dimethylphenylacetic acid is also referred to as 2-(4-methylphenyl)propanoic acid. It is an alkaline decomposition product of azalomycin-B, a macrolide antibiotic produced by Streptomyces hygroscopicus var. azalomyceticus. The reaction of pinonic acid with bromine in water affords 2-(4-methylphenyl)propanoic acid.

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