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| 4'-HYDROXYCHALCONE Basic information |
| Product Name: | 4'-HYDROXYCHALCONE | | Synonyms: | 2-Benzal-4'-hydroxyacetophenone
2-Benzylidene-4'-hydroxyacetophenone;1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one;1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one;4'-Hydroxychalcone,97%;4'-Hydroxychalcone 98%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone98%;HYDROXYCHALCONE, 4'- | | CAS: | 2657-25-2 | | MF: | C15H12O2 | | MW: | 224.25 | | EINECS: | | Product Categories: | Chalcones;Biochemistry;Flavonoids | | Mol File: | 2657-25-2.mol |
| 4'-HYDROXYCHALCONE Chemical Properties |
| Melting point | 174-178 °C | | Boiling point | 419.6±45.0 °C(Predicted) | | density | 1.191±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | pka | 7.72±0.15(Predicted) | | color | Light orange to Yellow to Green | | BRN | 2049150 | | InChIKey | UAHGNXFYLAJDIN-IZZDOVSWSA-N | | CAS DataBase Reference | 2657-25-2(CAS DataBase Reference) |
| 4'-HYDROXYCHALCONE Usage And Synthesis |
| Description | 4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner. | | Chemical Properties | yellow-cream powder | | Uses | antineoplastic, | | Uses | 4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV). | | Definition | ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'. |
| 4'-HYDROXYCHALCONE Preparation Products And Raw materials |
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