4-(Hydroxymethyl)benzoic acid

4-(Hydroxymethyl)benzoic acid
  • CAS No.:3006-96-0
Other grades of this product :
4-(Hydroxymethyl)benzoic acid Basic information
Product Name:4-(Hydroxymethyl)benzoic acid
Synonyms:HMBA;HMBA LINKER;4-CARBOXYBENZYL ALCOHOL;4-HYDROXYMETHYLBENZOIC ACID;RARECHEM AL BO 1443;HMBA LINKER,4-HYDROXYTHYLBENZOIC ACID;Hydroxymethylbenzoicacid;4-Hydroxythylbenzoic acid
CAS:3006-96-0
MF:C8H8O3
MW:152.15
EINECS:628-233-9
Product Categories:Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Linkers for Solid Phase Synthesis;Combinatorial Chemistry;Linkers;Synthetic Organic Chemistry;Biochemics;Bifunctional CrosslinkersCarbonyl Compounds;C8;Carboxylic Acids;Peptide Synthesis
Mol File:3006-96-0.mol
4-(Hydroxymethyl)benzoic acid Chemical Properties
Melting point 182-185 °C (lit.)
Boiling point 140-150 °C(Press: 9 Torr)
density 1.314±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO, Methanol
pka4.16±0.10(Predicted)
form Coarse Fibers
color White
BRN 2690023
InChIKeyWWYFPDXEIFBNKE-UHFFFAOYSA-N
CAS DataBase Reference3006-96-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
HS Code 29181990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
4-(Hydroxymethyl)benzoic acid Usage And Synthesis
Chemical PropertiesOff-white solid
Uses4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive age nt.
UsesThis linkage reagent for SPPS is essentially acid stable. It is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides.
Uses4-(Hydroxymethyl)benzoic Acid (Eprosartan USP Related Compound E) is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.
Synthesis Reference(s)Journal of the American Chemical Society, 107, p. 1365, 1985 DOI: 10.1021/ja00291a042
4-(Hydroxymethyl)benzoic acid Preparation Products And Raw materials
Preparation Products1-FORMYL-4-METHYLPIPERAZINE

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