ACETYLCHOLINE BROMIDE

CAS No.：66-23-9

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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ACETYLCHOLINE BROMIDE Basic information

Product Name:	ACETYLCHOLINE BROMIDE
Synonyms:	Acetylcholine bromide;2-(Acetyloxy)-N,N,N-trimethylethanaminium bromide;PRAGMOLINE;N-(2-HYDROXYETHYL)TRIMETHYLAMMONIUM BROMIDE ACETATE;2-ACETOXYETHYLTRIMETHYLAMMONIUM BROMIDE;ACH;ACETYLCHOLINE BROMIDE;(2-Hydroxyethyl)trimethylammoniumbromideacetate;2-(acetyloxy)-n,n,n-trimethyl-ethanaminiubromide
CAS:	66-23-9
MF:	C7H16BrNO2
MW:	226.11
EINECS:	200-622-4
Product Categories:	Ammonium Bromides (Quaternary);Quaternary Ammonium Compounds
Mol File:	66-23-9.mol

ACETYLCHOLINE BROMIDE Chemical Properties

Melting point	140-143 °C(lit.)
density	1.4246 (rough estimate)
refractive index	1.6120 (estimate)
storage temp.	-20°C
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
color	Off-White
Water Solubility	almost transparency
Sensitive	Hygroscopic
Merck	14,86
BRN	3572117
CAS DataBase Reference	66-23-9(CAS DataBase Reference)
EPA Substance Registry System	Acetylcholine bromide (66-23-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	FZ9680000
F	3-8-10-23
HS Code	29379000

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

ACETYLCHOLINE BROMIDE Usage And Synthesis

Chemical Properties	WHITE TO LIGHT BEIGE ADHERING CRYSTALLINE SOLID
Uses	Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions. Acetylcholine bromide is used as an acetylcholine receptor agonist to identify, characterize and differentiate among types of cholinergic receptors. Acetylcholine bromide is used as an inhibitor to identify and characterize natural and mutated butyrylcholinesterase(s).
Definition	ChEBI: The bromide salt of acetylcholine.
Biochem/physiol Actions	Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
Purification Methods	The bromide is a hygroscopic solid, but less so than the hydrochloride salt. It crystallises from EtOH as prisms. Some hydrolysis occurs in boiling EtOH, particularly if it contains some H2O. It can also be recrystallised from EtOH or MeOH by adding dry Et2O. [Heilbronn Acta Chem Scand 12 1492 1958, Beilstein 4 IV 1446.]

ACETYLCHOLINE BROMIDE Preparation Products And Raw materials

Raw materials

Ethanol-->Acetic anhydride-->Isopropyl alcohol-->Trimethylamine-->ACETALDEHYDE AMMONIA-->2-Bromoethanol-->Acetyl bromide

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