Product

4-Epoxypropanoxycarbazole

CAS No.：51997-51-4

Other grades of this product :

4-Epoxypropanoxycarbazole Basic information

Product Name:	4-Epoxypropanoxycarbazole
Synonyms:	Carvedilol Related Compound D (USP);4-EPOXYPROPANOXYCARBAZOLE;Carvedilol Epoxide Impurity;4-(2-Oxiranylmethyoxy)-9H-carbazole;4-OXIRANYLMETHOXY-9H-CARBAZOLE;4-GLYCIDYLOXYCARBAZOLE;4-(2-OXIRANYLMETHOXY)-9H-CARBAZOLE;Epoxide of Carvedilol
CAS:	51997-51-4
MF:	C15H13NO2
MW:	239.27
EINECS:	610-764-2
Product Categories:	Impurities;pharma material;Aromatics Compounds;Carbazoles;Oxiranes;Aromatics;Chemical intermediate for Benidipin;PHARMACEUTICAL INTERMEDIATES;(intermediate of carvedilol);Simple 3-Membered Ring Compounds;Carvedilol Intermediate
Mol File:	51997-51-4.mol

4-Epoxypropanoxycarbazole Chemical Properties

Melting point	130-132°C
Boiling point	464.9±15.0 °C(Predicted)
density	1.327±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	16.59±0.30(Predicted)
form	neat
color	Off-White to Light Brown
BRN	918742
InChIKey	SVWKIGRDISDRLO-UHFFFAOYSA-N
CAS DataBase Reference	51997-51-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	43-68
Safety Statements	36/37
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900

MSDS Information

4-Epoxypropanoxycarbazole Usage And Synthesis

Chemical Properties	Pale Yellow to Almost White Powder
Uses	4-(2,3-Epoxypropoxy)carbazole (Carvedilol EP Impurity D; Carvedilol USP-D) is an intermediate in the synthesis of Carvedilol (C184625).

4-Epoxypropanoxycarbazole Preparation Products And Raw materials

Raw materials	Benzenesulfonic acid, 3-nitro-, 2-oxiranylmethyl ester-->(S)-Oxiran-2-ylMethyl Methanesulfonate-->Cephaloridine-->1-Bromo-2,3-epoxypropane-->Epichlorohydrin-->Dimethyl sulfoxide-->4-Hydroxy carbazole
Preparation Products	Carvedilol Impurity 3-->N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol

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