2-Fluoropyridine

CAS No.：372-48-5

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2-Fluoropyridine Basic information

Synthesis

Product Name:	2-Fluoropyridine
Synonyms:	2-FLUOROPYRIDINE;2-Fluorpyridin;2-fluoro-pyridin;Pyridine, 2-fluoro-;2-Fluoropyride;2-Fluoroypyridine;2-Fluoropyridine,99%;2-CYANOPHENYLBORONIC ACID
CAS:	372-48-5
MF:	C5H4FN
MW:	97.09
EINECS:	206-757-5
Product Categories:	Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Pyridine;pyridine derivative;Pyridines;Fluoropyridines;Halopyridines;C5;Fluorine series;alkyl Fluorine;Fluorin-contained pyridine series;Heterocyclic Building Blocks;bc0001
Mol File:	372-48-5.mol

2-Fluoropyridine Chemical Properties

Boiling point	126 °C/753 mmHg (lit.)
density	1.128 g/mL at 25 °C (lit.)
refractive index	n20/D 1.466(lit.)
Fp	83 °F
storage temp.	Inert atmosphere,2-8°C
form	Liquid
pka	-0.44(at 25℃)
color	Clear colorless to light yellow
Specific Gravity	1.13
Water Solubility	Soluble in water.
BRN	1515
InChIKey	MTAODLNXWYIKSO-UHFFFAOYSA-N
CAS DataBase Reference	372-48-5(CAS DataBase Reference)
NIST Chemistry Reference	2-Fluoropyridine(372-48-5)

Safety Information

Hazard Codes	Xi,F,Xn
Risk Statements	10-36/37/38-20/21/22
Safety Statements	26-36-36/37/39-16
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	UT3900000
Hazard Note	Flammable/Irritant
HazardClass	3
PackingGroup	III
HS Code	29333999

MSDS Information

Provider	Language
2-Fluoropyridine	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Fluoropyridine Usage And Synthesis

Synthesis	A rare example of fluorodenitration of a heterocyclic system was provided by 2- nitropyridine, which was converted to 2-fluoropyridine.
Chemical Properties	CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Uses	2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.

2-Fluoropyridine Preparation Products And Raw materials

Raw materials	2(5H)-Pyridinone(9CI)-->2-PYRIDYL TRIFLUOROMETHANESULFONATE-->Perfluoro-2-methyl-2-pentene-->2,4,6-TRIFLUOROPYRIDINE-->2,4-DIFLUORO-PYRIDINE-->2-Nitropyridine
Preparation Products	2-(5-BROMO-2-THIENYL)PYRIDINE-->2-Fluoro-3-pyridylboronic acid-->2,6-Difluoropyridine-->Pyrrolidine, 2,2,3,3,4,4,5,5-octafluoro-1-(trifluoromethyl)--->2-Pyridylacetonitrile-->3-Bromo-2-fluoropyridine-->2-Fluoro-3-iodopyridine-->2-Fluoro-3,6-diiodopyridine

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