(S)-4-Hydroxy-2-pyrrolidinone

(S)-4-Hydroxy-2-pyrrolidinone
  • CAS No.:68108-18-9
Other grades of this product :
(S)-4-Hydroxy-2-pyrrolidinone Basic information
Product Name:(S)-4-Hydroxy-2-pyrrolidinone
Synonyms:2-PYRROLIDINONE, 4-HYDROXY-, (S);2-PYRROLIDINONE, 4-HYDROXY-, (4S)-;(4S)-4-HYDROXYPYRROLIDIN-2-ONE;4-HYDROXY-PYRROLIDIN-2-ONE;(s)-(-)-β-hydroxy-γ-butyrolactam;(s)-β-hydroxy-γ-butyrolactam;(S)-(-)-4-HYDROXY-2-PYRROLIDINONE;(S)-(+)-4-HYDROXY-2-PYRROLIDINONE
CAS:68108-18-9
MF:C4H7NO2
MW:101.1
EINECS:
Product Categories:Amines;Chiral Reagents;Chiral;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pyrrolidinone derivatives;Drug Intermediates
Mol File:68108-18-9.mol
(S)-4-Hydroxy-2-pyrrolidinone Chemical Properties
Melting point 156-159 °C (lit.)
alpha -41 º (c=% in ethanol)
Boiling point 363.6±35.0 °C(Predicted)
density 1.292±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
Water Solubility Slightly soluble in water
pka13.62±0.20(Predicted)
form Solid
color White to off-white
optical activity[α]23/D 43°, c = 1 in ethanol
BRN 1524192
InChIKeyIOGISYQVOGVIEU-VKHMYHEASA-N
CAS DataBase Reference68108-18-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 22-24/25-36-26
WGK Germany 3
HS Code 29349990
MSDS Information
ProviderLanguage
SigmaAldrich English
(S)-4-Hydroxy-2-pyrrolidinone Usage And Synthesis
Chemical PropertiesWhite crystal
Uses(S)-(?)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:
  • Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
  • Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.
UsesThe (S)-enantiomer intermediate in the preparation of Oxiracetam
General Description4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.
(S)-4-Hydroxy-2-pyrrolidinone Preparation Products And Raw materials

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