N-Isopropylacrylamide

N-Isopropylacrylamide
  • CAS No.:2210-25-5
Other grades of this product :
N-Isopropylacrylamide Basic information
Product Name:N-Isopropylacrylamide
Synonyms:N-isopropylacrylamide ,99%;N-Isopropylacrylamide ,99% [stabilized];-PropenaMide, N-(1-Methylethyl)-;N-IsopropylacrylaMide N-IsopropylacrylaMide, stabilized, pure, 99% 100GR;N-IsopropylacrylaMide, stabilized, pure, 99% 500GR;polyNIPAM-BA;N-IsopropylacrylaMide, 99%, stabilized with 500 ppM MEHQ
CAS:2210-25-5
MF:C6H11NO
MW:113.16
EINECS:218-638-5
Product Categories:Acrylamide and Methacrylamide;Acrylic Monomers;Monomers
Mol File:2210-25-5.mol
N-Isopropylacrylamide Chemical Properties
Melting point 60-63 °C(lit.)
Boiling point 89-92 °C2 mm Hg(lit.)
density 1.0223 (rough estimate)
refractive index 1.4210 (estimate)
storage temp. 2-8°C
form Crystalline Powder or Crystals
pka14.83±0.46(Predicted)
color White to light yellow
PHpH(50g/l, 25℃) : 7.8~10.0
Water Solubility Slightly soluble in water.
InChIKeyQNILTEGFHQSKFF-UHFFFAOYSA-N
CAS DataBase Reference2210-25-5(CAS DataBase Reference)
NIST Chemistry ReferenceAcrylamide, n-isopropyl-(2210-25-5)
EPA Substance Registry System2-Propenamide, N-(1-methylethyl)- (2210-25-5)
Safety Information
Hazard Codes Xn
Risk Statements 22-36-36/37/38
Safety Statements 26-36/37/39
WGK Germany 3
RTECS AS3675000
TSCA Yes
HS Code 29241990
Hazardous Substances Data2210-25-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
N-Isopropylacrylamide Usage And Synthesis
DescriptionN-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties, which include temperature-based volumetric and phase changes. These properties change when the temperature of the solution reaches a lower critical solution temperature (LCST).
Chemical Propertieswhite to light yellow crystalline powder or
UsesNIPAM can be used to prepare poly(NIPAM) for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.
UsesBinders in textiles, paper, adhesives, detergents, cosmetics.N-Isopropylacrylamide is used to produce poly(N-isopropylacrylamide) (pNIPA, pNIPAAm, pNIPAA or pNIPAm) thermo sensitive polymer- or copolymer-based hydrogels. Polymers that contain NIPAM shrink dramatically above 33°C. Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.
ApplicationN-Isopropylacrylamide (NIPAM) can be used to prepare poly(NIPAM) based thermosetting polymers, which can be used for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.Monomer used in the preparation of thermally sensitive, water-swellable hydrogels.
General DescriptionN-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties. These properties include temperature based volumetric and phase changes, which change when the temperature of the solution reaches a lower critical solution temperature (LCST).
Flammability and ExplosibilityNotclassified
Purification MethodsFractionate the amide under reduced pressure, and recrystallise the solid distillate from hexane (m 59o), *C6H6 (m 62o) or *C6H6/hexane (m 62-63o). Store it with 0.05% of 4-tert-butylcatechol. It is used for making water soluble swellable hydrogels. [Beilstein 4 IV 517.]

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