3-Bromo-2-fluorobenzoic acid

CAS No.：161957-56-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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3-Bromo-2-fluorobenzoic acid Basic information

Product Name:	3-Bromo-2-fluorobenzoic acid
Synonyms:	3-Bromo-2-fluorobenzoic acid 97%;Benzoic acid, 3-bromo-2-fluoro-;BUTTPARK 14\01-30;3-BROMO-2-FLUOROBENZOIC ACID;3-Bromo-2-fluorobenzoic;3-Bromo-2-fluorobenzoic acid 97%+;3-Bromo-2-fluorobenzoic Acid >2-fluoro-3-bromobenzoic acid,3-Bromo-2-fluoro-benzoic acid,3-Bromo-2-Fluorobenzoic acid
CAS:	161957-56-8
MF:	C7H4BrFO2
MW:	219.01
EINECS:
Product Categories:	Benzoic acid;API intermediates;Acids and Derivatives;Halides;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:	161957-56-8.mol

3-Bromo-2-fluorobenzoic acid Chemical Properties

Melting point	168 °C
Boiling point	298.2±25.0 °C(Predicted)
density	1.789±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	2.88±0.10(Predicted)
color	White to Light yellow
InChIKey	UVKURTLVTLRSSM-UHFFFAOYSA-N
CAS DataBase Reference	161957-56-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36
Safety Statements	26
HazardClass	IRRITANT
HS Code	2916399090

MSDS Information

Provider	Language
ALFA	English

3-Bromo-2-fluorobenzoic acid Usage And Synthesis

Chemical Properties

Off-white powder

Uses

3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).

3-Bromo-2-fluorobenzoic acid Preparation Products And Raw materials

Preparation Products

3-Bromo-2-fluoroaniline-->3-Bromo-2-fluorobenzoic acid methyl ester

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