| Butyl chloroformate Basic information |
| Product Name: | Butyl chloroformate |
| Synonyms: | N-BUTYL CHLOROFORMATE;Butoxycarbonyl chloride;Butyl chloridocarbonate;Butyl chlorocarbonate;carbonochloridicacid,butylester;carbonochloridicacidbutylester;Formic acid, chloro-, butyl ester;BUTYL CHLOROCARBOXYLATE |
| CAS: | 592-34-7 |
| MF: | C5H9ClO2 |
| MW: | 136.58 |
| EINECS: | 209-750-5 |
| Product Categories: | Acid Halides;Building Blocks;Acid Halides;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Pharmaceutical Intermediates;CHLOROFORMATES;Carbonyl Compounds;Organic Building Blocks |
| Mol File: | 592-34-7.mol |
| Butyl chloroformate Chemical Properties |
| Melting point | -70 °C |
| Boiling point | 142 °C(lit.) |
| density | 1.074 g/mL at 25 °C(lit.) |
| vapor pressure | 2.42 psi ( 20 °C) |
| refractive index | n |
| Fp | 77 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear |
| Water Solubility | DECOMPOSES |
| Sensitive | Moisture Sensitive |
| BRN | 605635 |
| CAS DataBase Reference | 592-34-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbonochloridic acid, butyl ester(592-34-7) |
| EPA Substance Registry System | n-Butyl chloroformate (592-34-7) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 10-23-34 |
| Safety Statements | 26-36-45 |
| RIDADR | UN 2743 6.1/PG 2 |
| WGK Germany | 1 |
| F | 10-19 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | I |
| HS Code | 29159020 |
| MSDS Information |
| Provider | Language |
|---|---|
| Butyl chloroformate | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Butyl chloroformate Usage And Synthesis |
| Chemical Properties | clear liquid |
| Uses | Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs. |
| General Description | A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals. |
| Air & Water Reactions | Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids. |
| Reactivity Profile | Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. |
| Health Hazard | Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach. |
| Flammability and Explosibility | Flammable |
| Butyl chloroformate Preparation Products And Raw materials |
| Raw materials | DIBUTYL CARBONATE-->1-Butanol-->Triphosgene-->Chloroform-->Diphosgene-->PHOSGENE |
| Preparation Products | 1-Chlorobutane-->Butyl formate |
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