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| DEHYDROABIETYLAMINE Basic information |
| Product Name: | DEHYDROABIETYLAMINE | | Synonyms: | (+)-DEHYDROABIETYLAMINE;DEHYDROABIETYLAMINE;(+)-DEHYDROABIETHYLAMINE;DEHYDROABIETHYLAMINE;D(+)-DEHYDROABIETYLAMINE;1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-;1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1.alpha.,4a.beta.,10a.alpha.)]1-Phenanthrenemethanamine;(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl-1-phenanthrenemethanamine) | | CAS: | 1446-61-3 | | MF: | C20H31N | | MW: | 285.47 | | EINECS: | 215-899-7 | | Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal | | Mol File: | 1446-61-3.mol |
| DEHYDROABIETYLAMINE Chemical Properties |
| Melting point | 44.50℃ | | Boiling point | 417.89°C (rough estimate) | | density | 0.963±0.06 g/cm3 (20 ºC 760 Torr) | | refractive index | n20/D 1.546(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform, DMSO, Methanol | | form | White solid. | | pka | 10.13±0.29(Predicted) | | color | Pale Yellow | | optical activity | [α]20/D +56.1°, c = 2.4 in pyridine | | BRN | 3084620 | | CAS DataBase Reference | 1446-61-3(CAS DataBase Reference) | | EPA Substance Registry System | Dehydroabietylamine (1446-61-3) |
| DEHYDROABIETYLAMINE Usage And Synthesis |
| Chemical Properties | clear yellow viscous liquid | | Uses | Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans. | | Biological Activity | CB 1 agonist. Displaces binding of [ 3 H]-SR141716A with an IC 50 value of 2.86 μ M. | | Purification Methods | The crude base is purified by converting 2g of base in toluene (3.3mL) into the acetate salt by heating at 65-70o with 0.46g of AcOH, and the crystals are collected and dried (0.96g from two crops, m 141-143o). The acetate salt is dissolved in warm H2O, basified with aqueous NaOH and extracted with *C6H6. The dried extract (MgSO4) is evaporated in vacuum leaving a viscous oil which crystallises and can be distilled. [Gottstein & Cheney J Org Chem 30 2072 1965.] The picrate has m 234-236o (from aqueous MeOH), and the formate has m 147-148o (from heptane). [Beilstein 12 IV 3005.] |
| DEHYDROABIETYLAMINE Preparation Products And Raw materials |
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