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| Hydroxyecdysone Basic information |
| Product Name: | Hydroxyecdysone | | Synonyms: | BETA-ECDYSONE;BETA-ECDYSONE,2,3,14,20,22,25-HEXAHYDROXY-7-CHOLESTEN-6-ONE;BETA-ECDYSTERONE;7,(5B)-CHOLESTEN-2BETA, 3BETA, 14ALPHA, 20BETA, 22R, 25-HEXOL-6-ONE;2B,3B,14A,20,22[R],25-HEXAHYDROXY-7-CHOLESTEN-6-ONE;2b,3b,14a,20b,22,25-hexahydroxycholest-7-en-6-one;2BETA,3BETA,14ALPHA,20BETA,22,25-HEXAHYDROXY-7-CHOLESTEN-6-ONE;(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-TRIHYDROXY-10,13-DIMETHYL-17-((1R,2R)-1,2,5-TRIHYDROXY-1,5-DIMETHYL-HEXYL)-1,2,3,4,5,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-6-ONE | | CAS: | 5289-74-7 | | MF: | C27H44O7 | | MW: | 480.64 | | EINECS: | 811-097-1 | | Product Categories: | Miscellaneous Natural Products;Steroids;Natural Plant Extract;sy;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors | | Mol File: | 5289-74-7.mol |
| Hydroxyecdysone Chemical Properties |
| Melting point | 242-244 °C | | Boiling point | 498.63°C (rough estimate) | | density | 1.0760 (rough estimate) | | refractive index | 1.5800 (estimate) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | alcohol: soluble | | form | powder | | pka | 14.13±0.70(Predicted) | | color | white | | Merck | 13,3525 | | BRN | 1917578 | | InChIKey | NKDFYOWSKOHCCO-YPVLXUMRSA-N | | CAS DataBase Reference | 5289-74-7(CAS DataBase Reference) |
| Hydroxyecdysone Usage And Synthesis |
| Chemical Properties | White or off-white powder | | Uses | insect molting hormone | | Uses | 20-Hydroxyecdysone has been used:- in Leibovitz′s dissecting medium for culturing sorting zone and neuropil-associated glia and antennal lobes of Manduca sexta
- in Schneider′s medium to reproduce ex-vivo imaginal disc eversion
- as a supplement in Mcl8 medium for culturing Drosophila wing imaginal discs
| | Definition | ChEBI: An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20. | | Biochem/physiol Actions | 20-Hydroxyecdysone is an ecdysteroid hormone that plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in molting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). | | Purification Methods | Crystallise -ecdyson from water, tetrahydrofuran/pet ether, MeOH and EtOAc after chromatographic purification. It has max (EtOH) at 240nm ( 12,670 M-1cm-1). [Also IR & NMR: Hüppi & Siddall J Am Chem Soc 89 6799 1967, Kametani et al. Tetrahedron Lett 21 4855 1980, Beilstein 8 IV 343.] |
| Hydroxyecdysone Preparation Products And Raw materials |
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