ISOXAZOLE-5-CARBOXYLIC ACID

ISOXAZOLE-5-CARBOXYLIC ACID
  • CAS No.:21169-71-1
Other grades of this product :
ISOXAZOLE-5-CARBOXYLIC ACID Basic information
Product Name:ISOXAZOLE-5-CARBOXYLIC ACID
Synonyms:TIMTEC-BB SBB004319;AKOS PAO-1371;ISOXAZOLE-5-CARBOXYLIC ACID;BUTTPARK 27\08-41;5-Isoxazolecarboxylic acid;Isoxazole-5-carboxylic acid 98%;Isoxazole-5-carboxylic acid ,98%;5-Carboxyisoxazole, 1,2-Oxazole-5-carboxylic acid, 5-Carboxy-1,2-oxazole
CAS:21169-71-1
MF:C4H3NO3
MW:113.07
EINECS:
Product Categories:carboxylic acid;Oxazole&Isoxazole;Building Blocks;Heterocyclic Building Blocks;Isoxazoles
Mol File:21169-71-1.mol
ISOXAZOLE-5-CARBOXYLIC ACID Chemical Properties
Melting point 144-148 °C(lit.)
Boiling point 211.74°C (rough estimate)
density 1.5808 (rough estimate)
refractive index 1.4543 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Powder
pka2.29±0.10(Predicted)
color Slightly yellow
Water Solubility Slightly soluble in water.
Sensitive Moisture Sensitive
InChIKeyMIIQJAUWHSUTIT-UHFFFAOYSA-N
CAS DataBase Reference21169-71-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-25-24-36-26
WGK Germany 3
HazardClass IRRITANT
HS Code 29349990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
ISOXAZOLE-5-CARBOXYLIC ACID Usage And Synthesis
Chemical Propertiesslightly yellow powder
UsesReaction conditions were found to allow the exclusive formation of isoxazole-5-carboxylic acid derivatives by conjugate addition, in acidic medium, of hydroxylamine to β-alkoxyvinyl trichloromethyl ketone in synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid participates in the Synthesis and evaluation of acylguanidine FXa inhibitors. 1, 1, 1-trichloro-4-methoxy-3-penten-2-one postulated in the preparation of isoxazole-5-carboxylic acid from trichloroacetyl chloride, ethyl vinyl ether and hydroxylamine is developed in a fully saturated nitrogen atom theerefore there is no possibility of conjugation with 4- substituents.
General DescriptionIsoxazole-5-carboxylic acid can be obtained via dehydration of 5-trichloromethylisoxazole.

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