abecarnil

CAS No.：111841-85-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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abecarnil Basic information

Product Name:	abecarnil
Synonyms:	6-(Benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid isopropyl ester;6-Benzyloxy-4-methoxymethyl-β-carboline-3-carboxylic acid isopropyl ester;Abercanil;ZK-112119;ZK-112-119;abecarnil;9H-Pyrido[3,4-b]indole-3-carboxylic acid, 4-(methoxymethyl)-6-(phenylmethoxy)-, 1-methylethyl ester
CAS:	111841-85-1
MF:	C24H24N2O4
MW:	404.46
EINECS:
Product Categories:
Mol File:	111841-85-1.mol

abecarnil Chemical Properties

Melting point	150-151°
CAS DataBase Reference	111841-85-1

Safety Information

MSDS Information

abecarnil Usage And Synthesis

Description	Abecarnil is a β-carboline-3-carboxylic acid derivative that is in development for the treatment of anxiety disorders. Animal work has shown that abecarnil has a low propensity to cause the problems of dependency and abuse and that the drug has marked anxiolytic and anticonvulsant activity but does not appear to have significant effects on motor coordination—a finding in marked contrast to the effects of diazepam (Stephens et al. 1990). This interesting phenomena may be explained by the fact that abecarnil is acting as a full agonist at some receptors that mediate certain effects (potent anxiolytic) and as a partial agonist at others (lack of side effects). One published clinical study compared abecarnil at different doses with placebo in patients with generalized anxiety disorder (Ballenger et al. 1991). This showed that abecarnil was significantly more effective than placebo in terms of anxiolysis. Stopping treatment produced no withdrawal effects in patients on the lower dose, although some effects were seen in those taking higher doses.
Originator	Abecarnil,Schepa
Uses	Abecarnil is a partial agonist at the benzodiazepine–GABA receptor complex, and is used in generalized anxiety disorder.
Therapeutic Function	Anticonvulsant, Anxiolytic
Hazard	Human systemic effects.

abecarnil Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->p-Anisaldehyde-->Hydrochloric acid-->tert-Butyl Hypochlorite-->Triethylamine-->Paraformaldehyde-->Potassium carbonate-->H-GLY-OIPR HCL

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