2-Bromo-4-methylaniline

CAS No.：583-68-6

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Bromo-4-methylaniline Basic information

Product Name:	2-Bromo-4-methylaniline
Synonyms:	2-bromo-4-methyl-benzenamin;2-Bromo-4-methylbenzenamine;2-Bromo-4-toluidine;2-bromo-p-toluidin;2-Bromo-4-methylaniline,99% (4-Amino-3-bromtoluol);2-Bromo-p-toluid;4-Amino-3-bromotoluene~2-Bromo-p-toluidine;2-Bromo-4-methylanline
CAS:	583-68-6
MF:	C7H8BrN
MW:	186.05
EINECS:	209-515-7
Product Categories:	Aromatic Hydrocarbons (substituted) & Derivatives;Anilines, Amides & Amines;Amines;blocks;Bromides;Bromine Compounds
Mol File:	583-68-6.mol

2-Bromo-4-methylaniline Chemical Properties

Melting point	14-16 °C (lit.)
Boiling point	240 °C (lit.)
density	1.5 g/mL at 25 °C (lit.)
refractive index	n20/D 1.602(lit.)
Fp	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly)
form	Oil
pka	2.97±0.10(Predicted)
color	Dark Yellow to Dark Beige
Specific Gravity	1.500
Water Solubility	Insoluble in water.
BRN	1931711
Stability:	Air Sensitive
InChIKey	UVRRJILIXQAAFK-UHFFFAOYSA-N
CAS DataBase Reference	583-68-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2-bromo-4-methyl-(583-68-6)
EPA Substance Registry System	Benzenamine, 2-bromo-4-methyl- (583-68-6)

Safety Information

Hazard Codes	T,Xi,Hazard
Risk Statements	23/24/25-36/37/38-33-20/21/22
Safety Statements	36/37/39-45-26
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	XU4300000
Hazard Note	Irritant/Toxic
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214300

MSDS Information

Provider	Language
4-Amino-3-bromotoluene	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Bromo-4-methylaniline Usage And Synthesis

Chemical Properties	clear light yellow to brown liquid
Uses	2-Bromo-4-methylaniline has been used in the synthesis of iminophosphoranes.
General Description	2-Bromo-4-methylaniline participates in palladium catalyzed selective amination of 3-bromoquinoline to yield 3-(2-bromo-4-methylphenylamino) quinoline. It reacts with ethyl and methyl imidazo[1,2-a]pyridine-2-carboxylates in the presence of Me₃Al to form amide.

2-Bromo-4-methylaniline Preparation Products And Raw materials

Raw materials	Sodium sulfite-->p-Acetotoluidide-->N-Acetyl-p-toluidine -->Silanamine, 1,1,1-trimethyl-N-(4-methylphenyl)--->methyl N-(2-bromo-4-methylphenyl)carbamate-->2-BROMO-4-METHYLANILINE HYDROCHLORIDE-->2-BroMo-4-Methyl-1-nitro-benzene-->2-Bromo-4-methylphenylboronic acid-->2-BROMO-N-METHYLANILINE 95
Preparation Products	3-Bromotoluene-->2-BROMO-4-METHYLBENZONITRILE-->5-Methylindole-->2-Bromo-4-methylphenol-->2'-BROMO-4'-METHYLACETANILIDE-->5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER-->5-METHYL-2-PHENYLINDOLE-->2-Chloro-6-methylbenzothiazole-->2-Amino-5-Methyl-Benzonitrile-->2-Bromo-4-methylbenzaldehyde

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