2-Amino-5-fluorobenzoic acid

CAS No.：446-08-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Amino-5-fluorobenzoic acid Basic information

Product Name:	2-Amino-5-fluorobenzoic acid
Synonyms:	2-AMINO-5-FLUOROBENZOIC ACID;RARECHEM AL BO 2236;2-AMino-5-fluorobenzoic acid, 97% 1GR;NSC 513308;2-aMino-5-fluorobenzoic aicd;2-Amino-5-fluorobenzoic acid 98%;5-Fluoroanthranilic acid, 2-Carboxy-4-fluoroaniline;Anthranilic acid, 5-fluoro-
CAS:	446-08-2
MF:	C7H6FNO2
MW:	155.13
EINECS:	207-159-7
Product Categories:	Aromatics;5-FOA;Nucleotides and Nucleosides;Benzoic acid Series;Bases & Related Reagents;Nucleotides;FINE Chemical & INTERMEDIATES;Fluorobenzene;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics Compounds;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid series;Amines;Fluorin-contained Benzoic acid series;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid;Fluorine series
Mol File:	446-08-2.mol

2-Amino-5-fluorobenzoic acid Chemical Properties

Melting point	181-183 °C(lit.)
Boiling point	223.67°C (rough estimate)
density	1.3021 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	1.86±0.10(Predicted)
form	Fine Crystalline Powder
color	Light yellow to light brown
BRN	2803664
InChIKey	FPQMGQZTBWIHDN-UHFFFAOYSA-N
CAS DataBase Reference	446-08-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,T
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29224999

MSDS Information

Provider	Language
5-Fluoroanthranilic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Amino-5-fluorobenzoic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	2-Amino-5-fluorobenzoic acid is used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.
Uses	Used in the synthesis of styrylquinazolinones which are potential anticancer agents.
Definition	ChEBI: An aminobenzoic acid that is anthranilic acid in which the hydrogen at position 5 on the phenyl ring is replaced by fluorine.

2-Amino-5-fluorobenzoic acid Preparation Products And Raw materials

Raw materials	5-Fluoro-2-nitrobenzoic acid-->2-Bromo-5-fluorobenzoic acid-->5-Fluoroindole-->2-ACETAMIDE-5-FLUOROTOLUENE-->2-ACETAMIDO-5-FLUOROBENZOIC ACID-->2-Amino-5-fluorobenzoic acid methyl ester-->5-Fluoro-2-nitrotoluene-->3-Fluorobenzoic acid
Preparation Products	2-AMINO-5-FLUOROACETOPHENONE-->6-FLUOROQUINAZOLIN-4-ONE-->6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine

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