Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-

CAS No.：178306-52-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Basic information

Uses

Product Name:	Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-
Synonyms:	Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-;(S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid;(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid;(S)-2-Hydroxyl -3-Methoxy-3,3-diphenylpropanoic acid;AMbrisentan InterMediate;Ambrisentan Hydroxy Acid Impurity;(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid;3-diphenylpropanoic acid
CAS:	178306-52-0
MF:	C16H16O4
MW:	272.3
EINECS:	1806241-263-5
Product Categories:	Drug Intermediates
Mol File:	178306-52-0.mol

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Chemical Properties

Melting point	121 °C
Boiling point	430.3±45.0 °C(Predicted)
density	1.248
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly)
pka	3.24±0.28(Predicted)
form	Solid
color	White to Off-White

Safety Information

MSDS Information

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Usage And Synthesis

Uses	(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity.
Chemical Properties	White powder
Uses	(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid is used in analytical studies for chiral discrimination of α-functionalized acids. Ambrisentan Hydroxy Acid Impurity

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS)- Preparation Products And Raw materials

Preparation Products

Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester

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