2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE

2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE
  • CAS No.:865758-95-8
Other grades of this product :
2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE Basic information
Product Name:2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE
Synonyms:2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE;2-((6-Chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile;2-[(6-Chloro-3,4-dihydro-2,4-dioxo-1(2H)-pyriMidinyl)Methyl]-benzonitrile;Agger coluMn dean interMediates;Benzonitrile, 2-[(6-chloro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-;Alogliptin Related Compound 27;ALOGLIPTIN int2;Alogliptin-5
CAS:865758-95-8
MF:C12H8ClN3O2
MW:261.66
EINECS:
Product Categories:
Mol File:865758-95-8.mol
2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE Chemical Properties
density 1.48
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Dichloromethane, Ethyl Acetate, Methanol
form Solid
pka8.11±0.40(Predicted)
color White
Safety Information
MSDS Information
2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE Usage And Synthesis
Chemical PropertiesWhite Solid
UsesAlogliptin (A575425) intermediate.
Uses2-((6-Chloro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl)benzonitrile is used as a reactant/ intermediate in discovery of Alogliptin (A575425), which is an antidiabetic agent.
2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE Preparation Products And Raw materials
Raw materials6-Chlorouracil-->2-Cyanobenzyl bromide
Preparation Products2-[(6-Chloro-3,4-dihydro-3-Methyl-2,4-dioxo-1(2h)-pyriMidinyl)Methyl]benzonitrile

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