3,4-(Methylenedioxy)cinnamic acid

CAS No.：2373-80-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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3,4-(Methylenedioxy)cinnamic acid Basic information

Product Name:	3,4-(Methylenedioxy)cinnamic acid
Synonyms:	3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid;3-(3,4-Methylene-dioxphenyl)acrylicacid;3-(3,4-Methylenedioxyphenyl)propenoic acid;3-(3,4-Methylenedioxyphenyl)propenoicacid;(2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoic acid;3,4-Methylenedioxybenzene-3-acrylic acid;Acetic acid, piperonylidene-;Cinnamic acid, 3,4-(methylenebis(oxy))-
CAS:	2373-80-0
MF:	C10H8O4
MW:	192.17
EINECS:	219-151-0
Product Categories:	Aromatic Cinnamic Acids, Esters and Derivatives;Cinnamic acid;C10;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
Mol File:	2373-80-0.mol

3,4-(Methylenedioxy)cinnamic acid Chemical Properties

Melting point	242-244 °C (dec.)(lit.)
Boiling point	248.14°C (rough estimate)
density	1.0825 (rough estimate)
refractive index	1.4440 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	very faint turbidity in Pyridine
form	powder to crystal
pka	4.37±0.10(Predicted)
color	White to Light yellow
BRN	84599
InChIKey	QFQYZMGOKIROEC-DUXPYHPUSA-N
CAS DataBase Reference	2373-80-0(CAS DataBase Reference)
NIST Chemistry Reference	3,4-Methylenedioxycinnamic acid(2373-80-0)

Safety Information

Hazard Codes	Xi
Risk Statements	38-36/37/38
Safety Statements	36-24/25-37-26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29329990

MSDS Information

Provider	Language
3,4-(Methylenedioxy)cinnamic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

3,4-(Methylenedioxy)cinnamic acid Usage And Synthesis

Chemical Properties	white to light yellow granular powder
Uses	3,4-(Methylenedioxy)cinnamic acid, predominantly trans is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase.
General Description	3,4-(Methylenedioxy)cinnamic acid is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. It undergoes electron transfer reaction with trichloromethylperoxyl radical and reaction has been studied by pulse radiolysis.
Purification Methods	Crystallise the acid from glacial AcOH, EtOH (m 247o) or aqueous EtOH (m 240-242o), and it has m 242o after sublimation. [Beilstein 19 H 278, 19 II 299, 19 III/IV 3548.]

3,4-(Methylenedioxy)cinnamic acid Preparation Products And Raw materials

Raw materials	Piperidine-->Potassium Acetate-->Piperonyl aldehyde
Preparation Products	3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOYL CHLORIDE-->savinin-->5-Hydroxy-1-indanone

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